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L-Carnitine

Vitamin E and L-Carnitine in Patients with End-stage Renal Disease

Posted January 12, 2014

In a prospective study involving 20 patients with end-stage renal disease on chronic hemodialysis with intradialytic complications such as hypotension, muscle cramp, nausea, vomiting, and headache, treatments with vitamin E (200 IU/d) and L-carnitine (500 mg/d), alone and in combination, were found to be effective in reducing these intradialytic complications.

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IVF Patients and L-Carnitine

Posted August 6, 2013

In a study involving 44 women undergoing IVF cycles (between 23 and 40 years of age, mean age: 32.3 years) with BMI between 17.3 and 34.7 (mean: 23.8) and 18 women of similar age (admitted for minor elective surgery) who served as controls, levels of serum free carnitine and acyclcarnitines were similar in IVF patients as compared to controls.

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L-Carnitine Improves Sperm Motility and Vitality

Posted August 3, 2013

In a study involving 22 male infertile patients, the effects of l-carnitine applied to sperm samples during cyropreservation (a process that influences reproductive outcomes in assisted reproductive outcomes of assisted reproductive technologies, but that significantly decreases sperm quality) as compared to sperm cyropreserved without L-carnitine, was examined.

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Topical Treatment with L-Carnitine for Mild to Moderately Severe Acne

Posted July 31, 2013

In a randomized, double-blind, vehicle-controlled, 9-week study involving 60 subjects with mild to moderately severe acne (10-25 inflammatory lesions) involving the face, application of a topical skin formulation containing licochalcone A, l-carnitine and 1,2-decanediol, twice a day for a period of 8 weeks, was found to be associated with a significant reduction in the pustules and sebum levels, marked reduction in P. acnes and improvement in DLQI, while no such changes were found in the group who applied a placebo vehicle.

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Protective Effects of L-Carnitine and Coenzyme Q10 on Toxicity of Statin Drugs

Posted June 11, 2013

In a study involving rat muscle fibers, 1-hour incubation with increasing concentrations of simvastatin (1-4 microM) was found to slow the rates of ADP-or FCCP-stimulated respiration supported by glutamate/malate in a dose-dependent manner, while causing no changes in resting respiration rates, and co-incubation of the muscle fibers with L-carnitine (1mM), mevalonate (100 microM), or coenzyme Q10 (10 microM) was found to “abolish simvastatin effects on both mitochondrial glutamate/malate-supported respiration and lactate release.

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L-Carnitine in the Secondary Prevention of Cardiovascular Disease

Posted May 9, 2013

In a systematic review and meta-analysis of 13 controlled trials (n=3629), supplementation with L-carnitine was found to be associated with a significant 27% reduction in all-cause mortality (OR=0.73), a highly significant 65% reduction in ventricular arrhythmias (RR=0.35), and a significant 40% reduction in the development of angina (RR=0.60), with no significant reduction in the development of heart failure (RR=0.85) or myocardial infarction (RR=0.78).

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Mayo Clinic review links L-Carnitine to multiple heart health benefits

Posted April 23, 2013

A systematic review by the Mayo Clinic has said that L-Carnitine can reduce mortality, abnormal heart rhythms and angina development in patients experiencing a heart attack.

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Study: L-Carnitine Significantly Improves Patient Outcomes Following Heart Attack

Posted April 15, 2013

L-carnitine significantly improves cardiac health in patients after a heart attack, say a multicenter team of investigators in a study published today in Mayo Clinic Proceedings. Their findings, based on analysis of key controlled trials, associate L-carnitine with significant reduction in death from all causes and a highly significant reduction in ventricular arrhythmias and anginal attacks following a heart attack, compared with placebo or control.

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L-Carnitine Retakes Spotlight, Hints at Survival Benefit in Acute MI: Meta-analysis

Posted April 13, 2013

A meta-analysis of 13 controlled trials concludes that including L-carnitine among the other therapies given in the acute setting for MI appears to significantly cut all-cause mortality and lead to fewer angina symptoms and ventricular arrhythmias. In some of the studies, L-carnitine therapy was subsequently given for six months to a year, suggesting a possible role not only in acute management but also secondary prevention, according to the authors.

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Study: Lower Dosage Carnipure Supplementation May Have Effects on Weight Management

Posted February 27, 2013

A new study confirmed the role of Carnipure (l-carnitine from supplier Lonza) supplementation combined with healthy lifestyle education on the success of weight management programs. The primary objective of this pilot, double-blind, randomized, placebocontrolled clinical trial conducted by the Japanese Clinical Research Organization Souken was to examine the effect of Carnipure tartrate providing a low dose of L-carnitine on weight management and energy metabolism-related parameters in overweight but healthy human subjects.

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