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Coenzyme Q10 Supplementation and Electron Transport Chain Activity and Mitochondrial Oxidative Stress

Posted March 7, 2014

In a study involving human SH-SY5Y neuronal cells with 1mM para-aminobenzoic acid (PABA) which induced a 54% decrease in cellular coenzyme Q10 status, treatment with 2.5 microM coenzyme Q10 for a period of 5 days significantly decreased the level of mitochondrial superoxide in the coenzyme Q10 deficient neurons, and 5 microM of coenzyme Q10 restored mitochondrial membrane potential to 90% of the control levels, while 10 microM coQ10 was only partially effective at restoring mitochondrial electron transport chain (ETC) enzyme activities.

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Coenzyme Q10 May Reverse Statin-Related Mitochondrial Dysfunction

Posted August 17, 2012

An experimental study involving statin-treated mice found that coenzyme Q10 could reverse atorvastatin-related mitochondrial dysfunction.

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Weight loss and increased fitness slow decline of mobility in adults

Posted April 30, 2012

Weight loss and increased physical fitness nearly halved the risk of losing mobility in overweight or obese adults with type 2 diabetes, according to four-year results from the Look AHEAD (Action for Health in Diabetes) trial funded by the National Institutes of Health. The results are published in the March 29, 2012, issue of the New England Journal of Medicine.

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