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Alzheimer’s/Brain Aging – Alternative Therapies

Posted January 3, 2012

Is vitamin E the magic bullet for the treatment of Alzheimer’s disease (AD)?

Woo, K. 2000. Is vitamin E the magic bullet for the treatment of Alzheimer’s disease (AD)? Perspectives 24 (1):7-10.

Should we encourage the use of high-dose vitamin E in persons with memory complaints as a preventive strategy against Alzheimer’s disease?

Gauthier, S. 2000. Should we encourage the use of high-dose vitamin E in persons with memory complaints as a preventive strategy against Alzheimer’s disease? J Psychiatry Neurosci 25 (4):394.

Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.

Di Matteo, V., and E. Esposito. 2003. Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Curr Drug Targets CNS Neurol Disord 2 (2):95-107.

Caloric intake and Alzheimer’s disease. Experimental approaches and therapeutic implications.

Pasinetti, G. M., Z. Zhao, W. Qin, L. Ho, Y. Shrishailam, D. Macgrogan, W. Ressmann, N. Humala, X. Liu, C. Romero, B. Stetka, L. Chen, H. Ksiezak-Reding, and J. Wang. 2007. Caloric intake and Alzheimer’s disease. Experimental approaches and therapeutic implications. Interdiscip Top Gerontol 35:159-75.

The role of hormone replacement therapy in the prevention of Alzheimer disease

Fillit, H. M. 2002. The role of hormone replacement therapy in the prevention of Alzheimer disease. Arch Intern Med 162 (17):1934-42.

Supplementation of the diet with silicic acid to reduce body burden of aluminum: A miracle cure or useless treatment for Alzheimer’s disease?

Savory, J., M. M. Herman, and O. Ghribi. 2006. Supplementation of the diet with silicic acid to reduce body burden of aluminum: a miracle cure or useless treatment for Alzheimer’s disease? J Alzheimers Dis 10 (1):25-7.

Nutritional Biomarkers in Alzheimer’s Disease: The Association between Carotenoids, n-3 Fatty Acids, and Dementia Severity

Wang, W., L. Shinto, W. E. Connor, and J. F. Quinn. 2008. Nutritional biomarkers in Alzheimer’s disease: the association between carotenoids, n-3 fatty acids, and dementia severity. J Alzheimers Dis 13 (1):31-8.

Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer’s disease-But how and why?

Das, U. N. 2008. Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer’s disease–but how and why? Prostaglandins Leukot Essent Fatty Acids 78 (1):11-9.

Dietary polyunsaturated fatty acid supplementation, pre-dementia syndromes, and Alzheimer’s disease.

Panza, F., C. Capurso, A. D’Introno, A. M. Colacicco, M. Chirico, A. Capurso, and V. Solfrizzi. 2007. Dietary polyunsaturated fatty acid supplementation, pre-dementia syndromes, and Alzheimer’s disease. J Am Geriatr Soc 55 (3):469-70.

Effects of hormone replacement therapy on cognitive and brain aging

Resnick, S. M., and P. M. Maki. 2001. Effects of hormone replacement therapy on cognitive and brain aging. Ann N Y Acad Sci 949:203-14.

Systematic review on the efficacy and safety of herbal medicines for Alzheimer’s disease.

Man, S. C., S. S. Durairajan, W. F. Kum, J. H. Lu, J. D. Huang, C. F. Cheng, V. Chung, M. Xu, and M. Li. 2008. Systematic review on the efficacy and safety of herbal medicines for Alzheimer’s disease. J Alzheimers Dis 14 (2):209-23.

Progress of study on treatment of Alzheimer’s disease with active ingredients of Chinese herbal medicines

Zhao, J. K., and D. S. Wang. 2008. [Progress of study on treatment of Alzheimer’s disease with active ingredients of Chinese herbal medicines]. Zhongguo Zhong Xi Yi Jie He Za Zhi 28 (2):177-81.

Inactivation of the human brain muscarinic acetylcholine receptor by oxidative damage catalyzed by a low molecular weight endogenous inhibitor from Alzheimer’s brain is prevented by pyrophosphate analogs, bioflavonoids and other antioxidants

Fawcett, J. R., E. Z. Bordayo, K. Jackson, H. Liu, J. Peterson, A. Svitak, and W. H. Frey, 2nd. 2002. Inactivation of the human brain muscarinic acetylcholine receptor by oxidative damage catalyzed by a low molecular weight endogenous inhibitor from Alzheimer’s brain is prevented by pyrophosphate analogs, bioflavonoids and other antioxidants. Brain Res 950 (1-2):10-20.

Vitamin E supplementation in Alzheimer’s disease, Parkinson’s disease, tardive dyskinesia, and cataract: Part 2

Pham, D. Q., and R. Plakogiannis. 2005. Vitamin E supplementation in Alzheimer’s disease, Parkinson’s disease, tardive dyskinesia, and cataract: Part 2. Ann Pharmacother 39 (12):2065-72.

Diet and the risk for Alzheimer’s disease

Kawas, C. H. 2006. Diet and the risk for Alzheimer’s disease. Ann Neurol 59 (6):877-9.

Antioxidant vitamins E and C and risk of Alzheimer’s disease

Martin, A. 2003. Antioxidant vitamins E and C and risk of Alzheimer’s disease. Nutr Rev 61 (2):69-73.

Diet and Alzheimer’s disease: what the evidence shows.

Morris, M. C. 2004. Diet and Alzheimer’s disease: what the evidence shows. MedGenMed 6 (1):48.

Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer’s disease differ according to apolipoprotein-E genotype

Craft, S., S. Asthana, G. Schellenberg, L. Baker, M. Cherrier, A. A. Boyt, R. N. Martins, M. Raskind, E. Peskind, and S. Plymate. 2000. Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer’s disease differ according to apolipoprotein-E genotype. Ann N Y Acad Sci 903:222-8.

Oxidative damage and Alzheimer’s disease: Are antioxidant therapies useful?

Moreira, P. I., M. A. Smith, X. Zhu, K. Honda, H. G. Lee, G. Aliev, and G. Perry. 2005. Oxidative damage and Alzheimer’s disease: are antioxidant therapies useful? Drug News Perspect 18 (1):13-9.

Improving cognition and function through exercise intervention in Alzheimer’s disease.

Yu, F., A. M. Kolanowski, N. E. Strumpf, and P. J. Eslinger. 2006. Improving cognition and function through exercise intervention in Alzheimer’s disease. J Nurs Scholarsh 38 (4):358-65.

Vitamin B status and cognitive performance in preclinical and clinical Alzheimer’s disease: data from the Kungsholmen Project.

Wahlin, A., K. Fahlander, T. B. Wahlin, D. Bunce, and L. Backman. 2008. Vitamin B status and cognitive performance in preclinical and clinical Alzheimer’s disease: data from the Kungsholmen Project. Dement Geriatr Cogn Disord 25 (1):23-31.

From asthma to alzheimer’s: Cochrane vitamin reviews cover an array of topics

Ezzo, J. 2005. From asthma to Alzheimer’s: Cochrane vitamin reviews cover an array of topics. J Altern Complement Med 11 (1):213-6.

Mediterranean diet, mild cognitive impairment, and Alzheimer’s disease

Panza, F., C. Capurso, A. D’Introno, A. M. Colacicco, A. Del Parigi, G. Gagliardi, G. Breglia, A. Capurso, and V. Solfrizzi. 2007. Mediterranean diet, mild cognitive impairment, and Alzheimer’s disease. Exp Gerontol 42 (1-2):6-7; author reply 8-9.

A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease

Aisen, P. S., S. Egelko, H. Andrews, R. Diaz-Arrastia, M. Weiner, C. DeCarli, W. Jagust, J. W. Miller, R. Green, K. Bell, and M. Sano. 2003. A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease. Am J Geriatr Psychiatry 11 (2):246-9.

Subnormal serum vitamin B12 and behavioural and psychological symptoms in Alzheimer’s disease

Meins, W., T. Muller-Thomsen, and H. P. Meier-Baumgartner. 2000. Subnormal serum vitamin B12 and behavioural and psychological symptoms in Alzheimer’s disease. Int J Geriatr Psychiatry 15 (5):415-8.

Vitamin E in neurodegenerative diseases 1

Khan, H. M., and M. Saeed. 2004. Vitamin E in neurodegenerative diseases. J Coll Physicians Surg Pak 14 (6):386.

Whole-diet approach, Mediterranean diet, and Alzheimer disease.

Solfrizzi, V., C. Capurso, A. D’Introno, A. M. Colacicco, M. Chirico, A. Capurso, and F. Panza. 2007. Whole-diet approach, Mediterranean diet, and Alzheimer disease. Arch Neurol 64 (4):606; author reply 607.

Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: A double blind, randomised, placebo controlled trial

Akhondzadeh, S., M. Noroozian, M. Mohammadi, S. Ohadinia, A. H. Jamshidi, and M. Khani. 2003. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 74 (7):863-6.

A nutritional education program could prevent weight loss and slow cognitive decline in Alzheimer’s disease.

Riviere, S., S. Gillette-Guyonnet, T. Voisin, E. Reynish, S. Andrieu, S. Lauque, A. Salva, G. Frisoni, F. Nourhashemi, M. Micas, and B. Vellas. 2001. A nutritional education program could prevent weight loss and slow cognitive decline in Alzheimer’s disease. J Nutr Health Aging 5 (4):295-9.

Increased risk of Alzheimer’s disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?

Biessels, G. J., and L. J. Kappelle. 2005. Increased risk of Alzheimer’s disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology? Biochem Soc Trans 33 (Pt 5):1041-4.

The role of insulin resistance in the pathogenesis of Alzheimer’s disease: implications for treatment.

Watson, G. S., and S. Craft. 2003. The role of insulin resistance in the pathogenesis of Alzheimer’s disease: implications for treatment. CNS Drugs 17 (1):27-45.

Herbal medicine in the treatment of Alzheimer’s disease.

Akhondzadeh, S., and S. H. Abbasi. 2006. Herbal medicine in the treatment of Alzheimer’s disease. Am J Alzheimers Dis Other Demen 21 (2):113-8.

Risk factors for Alzheimer’s disease: Role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment

Prasad, K. N., W. C. Cole, and K. C. Prasad. 2002. Risk factors for Alzheimer’s disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment. J Am Coll Nutr 21 (6):506-22.

Do dietary antioxidants prevent Alzheimer’s disease?

Sano, M. 2002. Do dietary antioxidants prevent Alzheimer’s disease? Lancet Neurol 1 (6):342.

Exercise, cognition and Alzheimer’s disease: More is not necessarily better

Eggermont, L., D. Swaab, P. Luiten, and E. Scherder. 2006. Exercise, cognition and Alzheimer’s disease: more is not necessarily better. Neurosci Biobehav Rev 30 (4):562-75.

Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study

Morris, M. C., D. A. Evans, J. L. Bienias, C. C. Tangney, D. A. Bennett, N. Aggarwal, R. S. Wilson, and P. A. Scherr. 2002. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 287 (24):3230-7.

Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements: The Cache County Study

Zandi, P. P., J. C. Anthony, A. S. Khachaturian, S. V. Stone, D. Gustafson, J. T. Tschanz, M. C. Norton, K. A. Welsh-Bohmer, and J. C. Breitner. 2004. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol 61 (1):82-8.

Bone mineral density and the risk of alzheimer disease

Tan, Z. S., S. Seshadri, A. Beiser, Y. Zhang, D. Felson, M. T. Hannan, R. Au, P. A. Wolf, and D. P. Kiel. 2005. Bone mineral density and the risk of Alzheimer disease. Arch Neurol 62 (1):107-11.

Exercise, aging, and Alzheimer disease

Larson, E. B., and L. Wang. 2004. Exercise, aging, and Alzheimer disease. Alzheimer Dis Assoc Disord 18 (2):54-6.

Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants

Liu, Q., F. Xie, R. Rolston, P. I. Moreira, A. Nunomura, X. Zhu, M. A. Smith, and G. Perry. 2007. Prevention and treatment of Alzheimer disease and aging: antioxidants. Mini Rev Med Chem 7 (2):171-80.

Effects of vitamin B12 on bright light on cognitive and sleep-wake rhythm in Alzheimer-type dementia

Ito, T., H. Yamadera, R. Ito, H. Suzuki, K. Asayama, and S. Endo. 2001. Effects of vitamin B12 on bright light on cognitive and sleep-wake rhythm in Alzheimer-type dementia. Psychiatry Clin Neurosci 55 (3):281-2.

Dietary intake of antioxidants and risk of Alzheimer disease: Food for thought

Foley, D. J., and L. R. White. 2002. Dietary intake of antioxidants and risk of Alzheimer disease: food for thought. JAMA 287 (24):3261-3.

Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia

Quadri, P., C. Fragiacomo, R. Pezzati, E. Zanda, G. Forloni, M. Tettamanti, and U. Lucca. 2004. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr 80 (1):114-22.

Antioxidants and risk of Alzheimer disease.

Varner, A. E. 2002. Antioxidants and risk of Alzheimer disease. JAMA 288 (18):2265; author reply 2265-6.

Antioxidants as a Potential Therapy Against Age-Related Neurodegenerative Diseases: Amyloid Beta Toxicity and Alzheimers Disease

Hajieva, P., and C. Behl. 2006. Antioxidants as a potential therapy against age-related neurodegenerative diseases: amyloid Beta toxicity and Alzheimer’s disease. Curr Pharm Des 12 (6):699-704.

Will antioxidants fulfill their expectations for the treatment of Alzheimer disease?

Rottkamp, C. A., A. Nunomura, K. Hirai, L. M. Sayre, G. Perry, and M. A. Smith. 2000. Will antioxidants fulfill their expectations for the treatment of Alzheimer disease? Mech Ageing Dev 116 (2-3):169-79.

Role of free radicals in the neurodegenerative diseases: Therapeutic implications for antioxidant treatment

Halliwell, B. 2001. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging 18 (9):685-716.

Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer’s beta-amyloid proteins

Fujiwara, H., K. Iwasaki, K. Furukawa, T. Seki, M. He, M. Maruyama, N. Tomita, Y. Kudo, M. Higuchi, T. C. Saido, S. Maeda, A. Takashima, M. Hara, Y. Ohizumi, and H. Arai. 2006. Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer’s beta-amyloid proteins. J Neurosci Res 84 (2):427-33.

Educating the brain to avoid dementia: Can mental exercise prevent Alzheimer disease?

Gatz, M. 2005. Educating the brain to avoid dementia: can mental exercise prevent Alzheimer disease? PLoS Med 2 (1):e7.

Effects of vitamin B12 on bright light on cognitive and sleep-wake rhythm in Alzheimer-type dementia.

Ito, T., H. Yamadera, R. Ito, H. Suzuki, K. Asayama, and S. Endo. 2001. Effects of vitamin B12 on bright light on cognitive and sleep-wake rhythm in Alzheimer-type dementia. Psychiatry Clin Neurosci 55 (3):281-2.

Exercise training for depressed older adults with Alzheimer’s disease.

Williams, C. L., and R. M. Tappen. 2008. Exercise training for depressed older adults with Alzheimer’s disease. Aging Ment Health 12 (1):72-80.

Antioxidant treatment in Alzheimer’s disease: Current state

Gilgun-Sherki, Y., E. Melamed, and D. Offen. 2003. Antioxidant treatment in Alzheimer’s disease: current state. J Mol Neurosci 21 (1):1-11.

Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology.

Beeri, M. S., J. Schmeidler, J. M. Silverman, S. Gandy, M. Wysocki, C. M. Hannigan, D. P. Purohit, G. Lesser, H. T. Grossman, and V. Haroutunian. 2008. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology 71 (10):750-7.

Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia

Kanowski, S., W. M. Herrmann, K. Stephan, W. Wierich, and R. Horr. 1996. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 29 (2):47-56.

Prevention and treatment of Alzheimer disease and aging: antioxidants.

Liu, Q., F. Xie, R. Rolston, P. I. Moreira, A. Nunomura, X. Zhu, M. A. Smith, and G. Perry. 2007. Prevention and treatment of Alzheimer disease and aging: antioxidants. Mini Rev Med Chem 7 (2):171-80.

Vitamin B12 plasma concentrations in Alzheimer disease.

Stuerenburg, H. J., T. Mueller-Thomsen, and A. Methner. 2004. Vitamin B 12 plasma concentrations in Alzheimer disease. Neuro Endocrinol Lett 25 (3):176-7.

Risk factors for Alzheimer’s disease: Role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment

Prasad, K. N., W. C. Cole, and K. C. Prasad. 2002. Risk factors for Alzheimer’s disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment. J Am Coll Nutr 21 (6):506-22.

Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements: The Cache County Study

Zandi, P. P., J. C. Anthony, A. S. Khachaturian, S. V. Stone, D. Gustafson, J. T. Tschanz, M. C. Norton, K. A. Welsh-Bohmer, and J. C. Breitner. 2004. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol 61 (1):82-8.