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Blood Sugar – Natural Treatments – Update since August 2016

Posted March 28, 2018

Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats.

Ahmed, O. M., M. A. Hassan, S. M. Abdel-Twab, and M. N. Abdel Azeem. “Navel Orange Peel Hydroethanolic Extract, Naringin and Naringenin Have Anti-Diabetic Potentials in Type 2 Diabetic Rats.” [In eng]. Biomed Pharmacother 94 (Oct 2017): 197-205.

Insulin Sensitivity and Diabetic Kidney Disease in Children and Adolescents With Type 2 Diabetes: An Observational Analysis of Data From the TODAY ClinicalTrial.

Bjornstad, P., E. Nehus, L. El Ghormli, F. Bacha, I. M. Libman, S. McKay, S. M. Willi, et al. “Insulin Sensitivity and Diabetic Kidney Disease in Children and Adolescents with Type 2 Diabetes: An Observational Analysis of Data from the Today Clinical Trial.” [In eng]. Am J Kidney Dis 71, no. 1 (Jan 2018): 65-74.

Chamomile and oregano extracts synergistically exhibit antihyperglycemic, antihyperlipidemic, and renal protective effects in alloxan-induced diabetic rats.

Prasanna, R., E. A. Ashraf, and M. A. Essam. “Chamomile and Oregano Extracts Synergistically Exhibit Antihyperglycemic, Antihyperlipidemic, and Renal Protective Effects in Alloxan-Induced Diabetic Rats.” [In eng]. Can J Physiol Pharmacol 95, no. 1 (Jan 2017): 84-92.

Virgin coconut oil reverses hepatic steatosis by restoring redox homeostasis and lipid metabolism in male Wistar rats.

Narayanankutty, A., D. M. Palliyil, K. Kuruvilla, and A. C. Raghavamenon. “Virgin Coconut Oil Reverses Hepatic Steatosis by Restoring Redox Homeostasis and Lipid Metabolism in Male Wistar Rats.” [In eng]. J Sci Food Agric 98, no. 5 (Mar 2018): 1757-64.

Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions.

Pittala, V., L. Vanella, L. Salerno, G. Romeo, A. Marrazzo, C. Di Giacomo, and V. Sorrenti. “Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions.” [In eng]. Curr Med Chem (Jun 16 2017).

Geraniol, a natural monoterpene, ameliorates hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats

Babukumar, S., V. Vinothkumar, C. Sankaranarayanan, and S. Srinivasan. “Geraniol, a Natural Monoterpene, Ameliorates Hyperglycemia by Attenuating the Key Enzymes of Carbohydrate Metabolism in Streptozotocin-Induced Diabetic Rats.” [In eng]. Pharm Biol 55, no. 1 (Dec 2017): 1442-49.

Structural analysis of the interaction between free, glycated and fructated hemoglobin with propolis nanoparticles: A spectroscopic study.

Kazemi, F., A. Divsalar, and A. A. Saboury. “Structural Analysis of the Interaction between Free, Glycated and Fructated Hemoglobin with Propolis Nanoparticles: A Spectroscopic Study.” [In eng]. Int J Biol Macromol 109 (Apr 1 2018): 1329-37.

Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: n-Glucosidase and n-Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects.

Sun, H., D. Wang, X. Song, Y. Zhang, W. Ding, X. Peng, X. Zhang, et al. “Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: Alpha-Glucosidase and Alpha-Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects.” [In eng]. J Agric Food Chem 65, no. 8 (Mar 1 2017): 1574-81.

Anti-hypoglycemic and hepatocyte-protective effects of hyperoside from Zanthoxylum bungeanum leaves in mice with high-carbohydrate/high-fat diet and alloxan-induced diabetes.

Zhang, Y., M. Wang, H. Dong, X. Yu, and J. Zhang. “Anti-Hypoglycemic and Hepatocyte-Protective Effects of Hyperoside from Zanthoxylum Bungeanum Leaves in Mice with High-Carbohydrate/High-Fat Diet and Alloxan-Induced Diabetes.” [In eng]. Int J Mol Med 41, no. 1 (Jan 2018): 77-86.

Effects of methyl mercury exposure on pancreatic beta cell development and function.

Schumacher, L., and L. C. Abbott. “Effects of Methyl Mercury Exposure on Pancreatic Beta Cell Development and Function.” [In eng]. J Appl Toxicol 37, no. 1 (Jan 2017): 4-12.

Modulation of both Insulin Resistance and Cancer Growth by Inositol.

Bizzarri, M., S. Dinicola, and A. Cucina. “Modulation of Both Insulin Resistance and Cancer Growth by Inositol.” [In eng]. Curr Pharm Des 23, no. 34 (2017): 5200-10.

Cytoprotective Effects of Pumpkin (Cucurbita Moschata) Fruit Extract against Oxidative Stress and Carbonyl Stress.

Shayesteh, R., M. Kamalinejad, H. Adiban, A. Kardan, F. Keyhanfar, and M. R. Eskandari. “Cytoprotective Effects of Pumpkin (Cucurbita Moschata) Fruit Extract against Oxidative Stress and Carbonyl Stress.” [In eng]. Drug Res (Stuttg) 67, no. 10 (Oct 2017): 576-82.

Differential n-amylase/ n-glucosidase inhibitory activities of plant-derived phenolic compounds: a virtual screening perspective for the treatment of obesity and diabetes.

Rasouli, H., S. M. Hosseini-Ghazvini, H. Adibi, and R. Khodarahmi. “Differential Alpha-Amylase/Alpha-Glucosidase Inhibitory Activities of Plant-Derived Phenolic Compounds: A Virtual Screening Perspective for the Treatment of Obesity and Diabetes.” [In eng]. Food Funct 8, no. 5 (May 24 2017): 1942-54.

DPP-4 inhibitor treatment: o-cell response but not HbA.

Kozlovski, P., V. Bhosekar, and J. E. Foley. “Dpp-4 Inhibitor Treatment: Beta-Cell Response but Not Hba1c Reduction Is Dependent on the Duration of Diabetes.” [In eng]. Vasc Health Risk Manag 13 (2017): 123-26.

Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors from Natural Products: Discovery of Next-Generation Antihyperglycemic Agents.

Choi, C. I. “Sodium-Glucose Cotransporter 2 (Sglt2) Inhibitors from Natural Products: Discovery of Next-Generation Antihyperglycemic Agents.” [In eng]. Molecules 21, no. 9 (Aug 27 2016).

DPP-4 inhibitor treatment: (beta)-cell response but not HbA1cspacereduction is dependent on the duration of diabetes.

Kozlovski, P., V. Bhosekar, and J. E. Foley. “Dpp-4 Inhibitor Treatment: Beta-Cell Response but Not Hba1c Reduction Is Dependent on the Duration of Diabetes.” [In eng]. Vasc Health Risk Manag 13 (2017): 123-26.

Vitamin E as a potential interventional treatment for metabolic syndrome: evidence from animal and human studies.

Wong, S. K., K. Y. Chin, F. H. Suhaimi, F. Ahmad, and S. Ima-Nirwana. “Vitamin E as a Potential Interventional Treatment for Metabolic Syndrome: Evidence from Animal and Human Studies.” [In eng]. Front Pharmacol 8 (2017): 444.

Antihyperglycemic, antioxidant activities of tucumoa oil (Astrocaryum vulgare) in alloxan-induced diabetic mice, and identification of fatty acid profile by gas chromatograph: New natural source to treat hyperglycemia.

Baldissera, M. D., C. F. Souza, T. H. Grando, L. F. Cossetin, M. R. Sagrillo, K. Nascimento, A. S. da Silva, et al. “Antihyperglycemic, Antioxidant Activities of Tucuma Oil (Astrocaryum Vulgare) in Alloxan-Induced Diabetic Mice, and Identification of Fatty Acid Profile by Gas Chromatograph: New Natural Source to Treat Hyperglycemia.” [In eng]. Chem Biol Interact 270 (May 25 2017): 51-58.

Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy.

Karuppagounder, V., S. Arumugam, V. V. Giridharan, R. Sreedhar, R. J. Bose, J. Vanama, S. S. Palaniyandi, et al. “Tiny Molecule, Big Power: Multi-Target Approach for Curcumin in Diabetic Cardiomyopathy.” [In eng]. Nutrition 34 (Feb 2017): 47-54.

Differential -amylase/-glucosidase inhibitory activities of plant-derived phenolic compounds: a virtual screening perspective for the treatment of obesity and diabetes.

Rasouli, H., S. M. Hosseini-Ghazvini, H. Adibi, and R. Khodarahmi. “Differential Alpha-Amylase/Alpha-Glucosidase Inhibitory Activities of Plant-Derived Phenolic Compounds: A Virtual Screening Perspective for the Treatment of Obesity and Diabetes.” [In eng]. Food Funct 8, no. 5 (May 24 2017): 1942-54.

Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus.

Vitak, T., B. Yurkiv, S. Wasser, E. Nevo, and N. Sybirna. “Effect of Medicinal Mushrooms on Blood Cells under Conditions of Diabetes Mellitus.” [In eng]. World J Diabetes 8, no. 5 (May 15 2017): 187-201.

Treatment with tucumoa oil (Astrocaryum vulgare) for diabetic mice prevents changes in seric enzymes of the purinergic system: Improvement of immune system.

Baldissera, M. D., C. F. Souza, P. H. Doleski, T. H. Grando, M. R. Sagrillo, A. S. da Silva, D. B. R. Leal, and S. G. Monteiro. “Treatment with Tucuma Oil (Astrocaryum Vulgare) for Diabetic Mice Prevents Changes in Seric Enzymes of the Purinergic System: Improvement of Immune System.” [In eng]. Biomed Pharmacother 94 (Oct 2017): 374-79.

Polyphenols: Novel Signaling Pathways.

Ricketts, M. L., and B. S. Ferguson. “Polyphenols: Novel Signaling Pathways.” [In eng]. Curr Pharm Des (Nov 29 2017).

Potential of the chlorogenic acid as multitarget agent: Insulin-secretagogue and PPAR n/ o dual agonist.

Sanchez, M. B., E. Miranda-Perez, J. C. G. Verjan, M. de Los Angeles Fortis Barrera, J. Perez-Ramos, and F. J. Alarcon-Aguilar. “Potential of the Chlorogenic Acid as Multitarget Agent: Insulin-Secretagogue and Ppar Alpha/Gamma Dual Agonist.” [In eng]. Biomed Pharmacother 94 (Oct 2017): 169-75.

Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: alpha-Glucosidase and alpha-Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects.

Sun, H., D. Wang, X. Song, Y. Zhang, W. Ding, X. Peng, X. Zhang, et al. “Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: Alpha-Glucosidase and Alpha-Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects.” [In eng]. J Agric Food Chem 65, no. 8 (Mar 1 2017): 1574-81.

Enhydrin Regulates Postprandial Hyperglycemia in Diabetic Rats by Inhibition of -Glucosidase Activity.

Serra-Barcellona, C., N. C. Habib, S. M. Honore, S. S. Sanchez, and S. B. Genta. “Enhydrin Regulates Postprandial Hyperglycemia in Diabetic Rats by Inhibition of Alpha-Glucosidase Activity.” [In eng]. Plant Foods Hum Nutr 72, no. 2 (Jun 2017): 156-60.

Diabetes for Cardiologists: Practical Issues in Diagnosis and Management.

Mancini, G. B., A. Y. Cheng, K. Connelly, D. Fitchett, R. Goldenberg, S. G. Goodman, L. A. Leiter, et al. “Diabetes for Cardiologists: Practical Issues in Diagnosis and Management.” [In eng]. Can J Cardiol 33, no. 3 (Mar 2017): 366-77.

Cordycepin stimulates autophagy in macrophages and prevents atherosclerotic plaque formation in ApoE.

Li, X., Y. Zhou, X. Zhang, X. Cao, C. Wu, and P. Guo. “Cordycepin Stimulates Autophagy in Macrophages and Prevents Atherosclerotic Plaque Formation in Apoe(-/-) Mice.” [In eng]. Oncotarget 8, no. 55 (Nov 7 2017): 94726-37.

A Chemically Modified Curcumin (CMC 2.24) Inhibits Nuclear Factor B Activation and Inflammatory Bone Loss in Murine Models of LPS-Induced Experimental Periodontitis and Diabetes-Associated Natural Periodontitis.

Elburki, M. S., C. Rossa, Jr., M. R. Guimaraes-Stabili, H. M. Lee, F. A. Curylofo-Zotti, F. Johnson, and L. M. Golub. “A Chemically Modified Curcumin (Cmc 2.24) Inhibits Nuclear Factor Kappab Activation and Inflammatory Bone Loss in Murine Models of Lps-Induced Experimental Periodontitis and Diabetes-Associated Natural Periodontitis.” [In eng]. Inflammation 40, no. 4 (Aug 2017): 1436-49.

Natural prenylchalconaringenins and prenylnaringenins as antidiabetic agents: -glucosidase and -amylase inhibition and in vivo antihyperglycemic and antihyperlipidemic effects.

Sun, H., D. Wang, X. Song, Y. Zhang, W. Ding, X. Peng, X. Zhang, et al. “Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: Alpha-Glucosidase and Alpha-Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects.” [In eng]. J Agric Food Chem 65, no. 8 (Mar 1 2017): 1574-81.

Nutrition for diabetic retinopathy: plummeting the inevitable threat of diabetic vision loss.

Sharma, Y., S. Saxena, A. Mishra, A. Saxena, and S. M. Natu. “Nutrition for Diabetic Retinopathy: Plummeting the Inevitable Threat of Diabetic Vision Loss.” [In eng]. Eur J Nutr 56, no. 6 (Sep 2017): 2013-27.

Synthetic and phytocompounds based dipeptidyl peptidase-IV (DPP-IV) inhibitors for therapeutics of diabetes.

Singh, A. K., R. Jatwa, A. Purohit, and H. Ram. “Synthetic and Phytocompounds Based Dipeptidyl Peptidase-Iv (Dpp-Iv) Inhibitors for Therapeutics of Diabetes.” [In eng]. J Asian Nat Prod Res 19, no. 10 (Oct 2017): 1036-45.

Enhydrin regulates postprandial hyperglycemia in diabetic rats by inhibition of -glucosidase activity.

Serra-Barcellona, C., N. C. Habib, S. M. Honore, S. S. Sanchez, and S. B. Genta. “Enhydrin Regulates Postprandial Hyperglycemia in Diabetic Rats by Inhibition of Alpha-Glucosidase Activity.” [In eng]. Plant Foods Hum Nutr 72, no. 2 (Jun 2017): 156-60.

SIRT1 as a therapeutic target in diabetic complications.

Strycharz, J., Z. Rygielska, E. Swiderska, J. Drzewoski, J. Szemraj, L. Szmigiero, and A. Sliwinska. “Sirt1 as a Therapeutic Target in Diabetic Complications.” [In eng]. Curr Med Chem (Nov 6 2017).

Enhydrin Regulates Postprandial Hyperglycemia in Diabetic Rats by Inhibition of alpha-Glucosidase Activity.

Serra-Barcellona, C., N. C. Habib, S. M. Honore, S. S. Sanchez, and S. B. Genta. “Enhydrin Regulates Postprandial Hyperglycemia in Diabetic Rats by Inhibition of Alpha-Glucosidase Activity.” [In eng]. Plant Foods Hum Nutr 72, no. 2 (Jun 2017): 156-60.

An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes.

Ota, A., and N. P. Ulrih. “An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes.” [In eng]. Front Pharmacol 8 (2017): 436.

Anti-diabetic potential of peptides: Future prospects as therapeutic agents.

Marya, H. Khan, S. M. Nabavi, and S. Habtemariam. “Anti-Diabetic Potential of Peptides: Future Prospects as Therapeutic Agents.” [In eng]. Life Sci 193 (Jan 15 2018): 153-58.

Efficacy of Cordyceps sinensis as an adjunctive treatment in kidney transplant patients: A systematic-review and meta-analysis.

Ong, B. Y., and Z. Aziz. “Efficacy of Cordyceps Sinensis as an Adjunctive Treatment in Kidney Transplant Patients: A Systematic-Review and Meta-Analysis.” [In eng]. Complement Ther Med 30 (Feb 2017): 84-92.

10-Hydroxy-2-decenoic acid, a natural product, improves hyperglycemia and insulin resistance in obese/diabetic KK-Ay mice, but does not prevent obesity.

Watadani, R., J. Kotoh, D. Sasaki, A. Someya, K. Matsumoto, and A. Maeda. “10-Hydroxy-2-Decenoic Acid, a Natural Product, Improves Hyperglycemia and Insulin Resistance in Obese/Diabetic Kk-Ay Mice, but Does Not Prevent Obesity.” [In eng]. J Vet Med Sci 79, no. 9 (Sep 29 2017): 1596-602.

Multiple therapeutic effect of endothelial progenitor cell regulated by drugs in diabetes and diabetes related disorder.

Ambasta, R. K., H. Kohli, and P. Kumar. “Multiple Therapeutic Effect of Endothelial Progenitor Cell Regulated by Drugs in Diabetes and Diabetes Related Disorder.” [In eng]. J Transl Med 15, no. 1 (Aug 31 2017): 185.

MicroRNAs 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes via Pancreatic -Cell Proliferation.

Tsukita, S., T. Yamada, K. Takahashi, Y. Munakata, S. Hosaka, H. Takahashi, J. Gao, et al. “Micrornas 106b and 222 Improve Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes Via Pancreatic Beta-Cell Proliferation.” [In eng]. EBioMedicine 15 (Feb 2017): 163-72.

Baicalin attenuates In Vivo and In Vitro hyperglycemia-exacerbated ischemia/ reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK.

Li, S., X. Sun, L. Xu, R. Sun, Z. Ma, X. Deng, B. Liu, et al. “Baicalin Attenuates in Vivo and in Vitro Hyperglycemia-Exacerbated Ischemia/Reperfusion Injury by Regulating Mitochondrial Function in a Manner Dependent on Ampk.” [In eng]. Eur J Pharmacol 815 (Nov 15 2017): 118-26.

Encapsulation of 16-Hydroxycleroda-3,13-Dine-16,15-Olide in Mesoporous Silica Nanoparticles as a Natural Dipeptidyl Peptidase-4 Inhibitor Potentiated Hypoglycemia in Diabetic Mice.

Huang, P. K., S. X. Lin, M. J. Tsai, M. K. Leong, S. R. Lin, R. K. Kankala, C. H. Lee, and C. F. Weng. “Encapsulation of 16-Hydroxycleroda-3,13-Dine-16,15-Olide in Mesoporous Silica Nanoparticles as a Natural Dipeptidyl Peptidase-4 Inhibitor Potentiated Hypoglycemia in Diabetic Mice.” [In eng]. Nanomaterials (Basel) 7, no. 5 (May 12 2017).

The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review.

Kershaw, J., and K. H. Kim. “The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review.” [In eng]. J Med Food 20, no. 5 (May 2017): 427-38.

Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4.

Wang, Z., L. Yang, H. Fan, P. Wu, F. Zhang, C. Zhang, W. Liu, and M. Li. “Screening of a Natural Compound Library Identifies Emodin, a Natural Compound from Rheum Palmatum Linn That Inhibits Dpp4.” [In eng]. PeerJ 5 (2017): e3283.

Targeting Mitochondrial Dysfunction for the Treatment of Diabetic Complications: Pharmacological Interventions through Natural Products.

Kaikini, A. A., D. M. Kanchan, U. N. Nerurkar, and S. Sathaye. “Targeting Mitochondrial Dysfunction for the Treatment of Diabetic Complications: Pharmacological Interventions through Natural Products.” [In eng]. Pharmacogn Rev 11, no. 22 (Jul-Sep 2017): 128-35.

Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2.

Dludla, P. V., E. Joubert, C. J. F. Muller, J. Louw, and R. Johnson. “Hyperglycemia-Induced Oxidative Stress and Heart Disease-Cardioprotective Effects of Rooibos Flavonoids and Phenylpyruvic Acid-2-O-Beta-D-Glucoside.” [In eng]. Nutr Metab (Lond) 14 (2017): 45.