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Blood Thinners – Efficacy for Natural versus Synthetic

Posted March 28, 2018

Comparison of bioavailability and antiplatelet action of ticagrelor in patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction: A prospective, observational, single-centre study.

Adamski, P., J. Sikora, E. Laskowska, K. Buszko, M. Ostrowska, J. M. Uminska, A. Sikora, et al. “Comparison of Bioavailability and Antiplatelet Action of Ticagrelor in Patients with St-Elevation Myocardial Infarction and Non-St-Elevation Myocardial Infarction: A Prospective, Observational, Single-Centre Study.” [In eng]. PLoS One 12, no. 10 (2017): e0186013.

Design, synthesis and antithrombotic evaluation of novel non-peptide thrombin inhibitors.

Chen, D., J. Shi, J. Liu, X. Zhang, X. Deng, Y. Yang, S. Cui, et al. “Design, Synthesis and Antithrombotic Evaluation of Novel Non-Peptide Thrombin Inhibitors.” [In eng]. Bioorg Med Chem 25, no. 2 (Jan 15 2017): 458-70.

Antifibrotic effect of total flavonoids of Astmgali Radix on dimethylnitrosamine-induced liver cirrhosis in rats.

Cheng, Y., J. Y. Mai, M. F. Wang, G. F. Chen, and J. Ping. “Antifibrotic Effect of Total Flavonoids of Astmgali Radix on Dimethylnitrosamine-Induced Liver Cirrhosis in Rats.” [In eng]. Chin J Integr Med 23, no. 1 (Jan 2017): 48-54.

Purification and partial characterization of a low molecular fibrinolytic serine metalloprotease C142 from the culture supernatant of Bacillus subtilis C142.

Choi, J. H., J. E. Kim, S. Kim, J. Yoon, D. H. Park, H. J. Shin, H. J. Lee, and S. S. Cho. “Purification and Partial Characterization of a Low Molecular Fibrinolytic Serine Metalloprotease C142 from the Culture Supernatant of Bacillus Subtilis C142.” [In eng]. Int J Biol Macromol 104, no. Pt A (Nov 2017): 724-31.

Synthesis, antiplatelet and antithrombotic activities of resveratrol derivatives with NO-donor properties.

Dutra, L. A., J. F. O. Guanaes, N. Johmann, M. E. Lopes Pires, C. M. Chin, S. Marcondes, and J. L. Dos Santos. “Synthesis, Antiplatelet and Antithrombotic Activities of Resveratrol Derivatives with No-Donor Properties.” [In eng]. Bioorg Med Chem Lett 27, no. 11 (Jun 1 2017): 2450-53.

Bivalirudin versus Heparin Monotherapy in Myocardial Infarction.

Erlinge, D., E. Omerovic, O. Frobert, R. Linder, M. Danielewicz, M. Hamid, E. Swahn, et al. “Bivalirudin Versus Heparin Monotherapy in Myocardial Infarction.” [In eng]. N Engl J Med 377, no. 12 (Sep 21 2017): 1132-42.

From head to toe: Sex and gender differences in the treatment of ischemic cerebral disease.

Falsetti, L., G. Viticchi, L. Buratti, C. Balucani, A. M. Marra, and M. Silvestrini. “From Head to Toe: Sex and Gender Differences in the Treatment of Ischemic Cerebral Disease.” [In eng]. Pharmacol Res 121 (Jul 2017): 240-50.

Protein profile analysis of two australian snake venoms by one-dimensional gel electrophoresis and MS/MS experiments.

Georgieva, D., D. Hildebrand, R. Simas, M. A. Coronado, M. Kwiatkowski, H. Schluter, R. Arni, P. Spencer, and C. Betzel. “Protein Profile Analysis of Two Australian Snake Venoms by One- Dimensional Gel Electrophoresis and Ms/Ms Experiments.” [In eng]. Curr Med Chem 24, no. 17 (2017): 1892-908.

Antithrombotic therapy strategies for atrial fibrillation patients undergoing percutaneous coronary intervention: A systematic review and network meta-analysis.

Gong, X., S. Tang, J. Li, X. Zhang, X. Tian, and S. Ma. “Antithrombotic Therapy Strategies for Atrial Fibrillation Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Network Meta-Analysis.” [In eng]. PLoS One 12, no. 10 (2017): e0186449.

Comparative Efficacy of Clinical Events Prevention of Five Anticoagulants in Patients With Atrial Fibrillation (A Network Meta-Analysis).

Guo, L., S. Li, P. Wang, X. Zhong, and Y. Hong. “Comparative Efficacy of Clinical Events Prevention of Five Anticoagulants in Patients with Atrial Fibrillation (a Network Meta-Analysis).” [In eng]. Am J Cardiol 119, no. 4 (Feb 15 2017): 585-93.

The genus Achyranthes: A review on traditional uses, phytochemistry, and pharmacological activities.

He, X., X. Wang, J. Fang, Y. Chang, N. Ning, H. Guo, L. Huang, and X. Huang. “The Genus Achyranthes: A Review on Traditional Uses, Phytochemistry, and Pharmacological Activities.” [In eng]. J Ethnopharmacol 203 (May 5 2017): 260-78.

Comparative efficacy and safety of anticoagulants for prevention of venous thromboembolism after hip and knee arthroplasty.

Hur, M., S. K. Park, C. H. Koo, E. D. Jung, P. Kang, W. H. Kim, J. T. Kim, C. W. Jung, and J. H. Bahk. “Comparative Efficacy and Safety of Anticoagulants for Prevention of Venous Thromboembolism after Hip and Knee Arthroplasty.” [In eng]. Acta Orthop 88, no. 6 (Dec 2017): 634-41.

Comparative efficacy and safety of reperfusion therapy with fibrinolytic agents in patients with ST-segment elevation myocardial infarction: a systematic review and network meta-analysis.

Jinatongthai, P., J. Kongwatcharapong, C. Y. Foo, A. Phrommintikul, S. Nathisuwan, A. Thakkinstian, C. M. Reid, and N. Chaiyakunapruk. “Comparative Efficacy and Safety of Reperfusion Therapy with Fibrinolytic Agents in Patients with St-Segment Elevation Myocardial Infarction: A Systematic Review and Network Meta-Analysis.” [In eng]. Lancet 390, no. 10096 (Aug 19 2017): 747-59.

Comparison of the efficacy of fixed-dose enoxaparin and adjusted-dose unfractionated heparin in patients with cerebral venous thrombosis.

Korathanakhun, P., C. Petpichetchian, W. Petpichetchian, and P. Sathirapanya. “Comparison of the Efficacy of Fixed-Dose Enoxaparin and Adjusted-Dose Unfractionated Heparin in Patients with Cerebral Venous Thrombosis.” [In eng]. Clin Neurol Neurosurg 159 (Aug 2017): 50-54.

Fish oil attenuates neurologic severity of antiphospholipid syndrome in a mice experimental model.

Maalouly, G., C. Ward, V. Smayra, Y. Saliba, G. Aftimos, F. Haddad, and N. Fares. “Fish Oil Attenuates Neurologic Severity of Antiphospholipid Syndrome in a Mice Experimental Model.” [In eng]. Nutr Neurosci 20, no. 10 (Dec 2017): 563-70.

Panax ginseng and Panax quinquefolius: From pharmacology to toxicology.

Mancuso, C., and R. Santangelo. “Panax Ginseng and Panax Quinquefolius: From Pharmacology to Toxicology.” [In eng]. Food Chem Toxicol 107, no. Pt A (Sep 2017): 362-72.

Synthesis and biological evaluation of C-3 aliphatic coumarins as vitamin K antagonists.

Montagut-Romans, A., M. Boulven, M. Jacolot, S. Moebs-Sanchez, C. Hascoet, A. Hammed, S. Besse, et al. “Synthesis and Biological Evaluation of C-3 Aliphatic Coumarins as Vitamin K Antagonists.” [In eng]. Bioorg Med Chem Lett 27, no. 7 (Apr 1 2017): 1598-601.

Inhibitory effect of Campomanesia xanthocarpa in platelet aggregation: Comparison and synergism with acetylsalicylic acid.

Otero, J. S., G. E. Hirsch, J. Z. Klafke, F. G. Porto, A. S. de Almeida, S. Nascimento, A. Schmidt, et al. “Inhibitory Effect of Campomanesia Xanthocarpa in Platelet Aggregation: Comparison and Synergism with Acetylsalicylic Acid.” [In eng]. Thromb Res 154 (Jun 2017): 42-49.

Pharmacokinetic comparison of two phenolic acids after oral administration of Typhae pollen to normal rats and rats with acute cold blood stasis.

Pan, Y., W. Zhang, X. Bai, S. Ren, J. Zheng, D. Wang, and X. Liu. “Pharmacokinetic Comparison of Two Phenolic Acids after Oral Administration of Typhae Pollen to Normal Rats and Rats with Acute Cold Blood Stasis.” [In eng]. Biomed Chromatogr 31, no. 12 (Dec 2017).

Rationale and Design for a Randomized Comparison of Efficacy and Safety between Aspirin and Clopidogrel in Atrial Fibrillation Patients with Low Stroke Risk: CESAC-AF trial.

Park, S. M., H. Jeong, M. H. Jung, K. S. Hong, M. K. Hong, C. S. Bang, and C. Y. Kim. “Rationale and Design for a Randomized Comparison of Efficacy and Safety between Aspirin and Clopidogrel in Atrial Fibrillation Patients with Low Stroke Risk: Cesac-Af Trial.” [In eng]. Contemp Clin Trials 60 (Sep 2017): 51-55.

Hierarchical identification of bioactive components in a medicinal herb by preparative high-performance liquid chromatography and selective knock-out strategy.

Qu, C., L. Y. Wang, H. Lin, E. X. Shang, Y. P. Tang, S. J. Yue, Y. Jin, et al. “Hierarchical Identification of Bioactive Components in a Medicinal Herb by Preparative High-Performance Liquid Chromatography and Selective Knock-out Strategy.” [In eng]. J Pharm Biomed Anal 135 (Feb 20 2017): 206-16.

Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors.

Sakurada, I., T. Endo, K. Hikita, T. Hirabayashi, Y. Hosaka, Y. Kato, Y. Maeda, et al. “Discovery of Novel Aminobenzisoxazole Derivatives as Orally Available Factor Ixa Inhibitors.” [In eng]. Bioorg Med Chem Lett 27, no. 11 (Jun 1 2017): 2622-28.

Metabolic syndrome: Sex-related cardiovascular risk & therapeutic approach.

Santilli, F., D. D’Ardes, M. T. Guagnano, and G. Davi. “Metabolic Syndrome: Sex-Related Cardiovascular Risk and Therapeutic Approach.” [In eng]. Curr Med Chem 24, no. 24 (2017): 2602-27.

Comparison of Therapeutic Efficacy of Anticoagulation and Its Combination with Catheter-directed Thrombolysis for Deep Venous Thrombosis of Lower Extremitiesa.

Su, S. F., Y. F. Tian, L. B. Chen, and B. Yan. “[Comparison of Therapeutic Efficacy of Anticoagulation and Its Combination with Catheter-Directed Thrombolysis for Deep Venous Thrombosis of Lower Extremities].” [In chi]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 25, no. 5 (Oct 2017): 1509-13.

Design, synthesis, and biological activity of novel tetrahydropyrazolopyridone derivatives as FXa inhibitors with potent anticoagulant activity.

Sun, X., Z. Hong, M. Liu, S. Guo, D. Yang, Y. Wang, T. Lan, et al. “Design, Synthesis, and Biological Activity of Novel Tetrahydropyrazolopyridone Derivatives as Fxa Inhibitors with Potent Anticoagulant Activity.” [In eng]. Bioorg Med Chem 25, no. 10 (May 15 2017): 2800-10.

Purification, partial characterization and bioactivity of sulfated polysaccharides from Grateloupia livida.

Tang, L., Y. Chen, Z. Jiang, S. Zhong, W. Chen, F. Zheng, and G. Shi. “Purification, Partial Characterization and Bioactivity of Sulfated Polysaccharides from Grateloupia Livida.” [In eng]. Int J Biol Macromol 94, no. Pt A (Jan 2017): 642-52.

Evaluation of the Efficacy and Safety of Direct Oral Anticoagulants in Japanese Patients-Analysis of Pharmaceuticals and Medical Devices Agency Data.

Terayama, Y. “Evaluation of the Efficacy and Safety of Direct Oral Anticoagulants in Japanese Patients-Analysis of Pharmaceuticals and Medical Devices Agency Data.” [In eng]. J Stroke Cerebrovasc Dis 26, no. 6 (Jun 2017): 1171-81.

Transition of Intravenous Treprostinil to Oral Therapy in a Patient with Functional Class IV Chronic Thromboembolic Pulmonary Hypertension.

Thurber, K. M., B. M. Williams, R. E. Bates, and R. P. Frantz. “Transition of Intravenous Treprostinil to Oral Therapy in a Patient with Functional Class Iv Chronic Thromboembolic Pulmonary Hypertension.” [In eng]. Pharmacotherapy 37, no. 8 (Aug 2017): e76-e81.

Ex vivo blood vessel bioreactor for analysis of the biodegradation of magnesium stent models with and without vessel wall integration.

Wang, J., L. Liu, Y. Wu, M. F. Maitz, Z. Wang, Y. Koo, A. Zhao, et al. “Ex Vivo Blood Vessel Bioreactor for Analysis of the Biodegradation of Magnesium Stent Models with and without Vessel Wall Integration.” [In eng]. Acta Biomater 50 (Mar 1 2017): 546-55.

Synthesis of 3-O-Sulfated Oligosaccharides to Understand the Relationship between Structures and Functions of Heparan Sulfate.

Wang, Z., P. H. Hsieh, Y. Xu, D. Thieker, E. J. Chai, S. Xie, B. Cooley, et al. “Synthesis of 3-O-Sulfated Oligosaccharides to Understand the Relationship between Structures and Functions of Heparan Sulfate.” [In eng]. J Am Chem Soc (Apr 3 2017).

Blockade of protease-activated receptor- 4(PAR4) provides robust antithrombotic activity with low bleeding.

Wong, P. C., D. Seiffert, J. E. Bird, C. A. Watson, J. S. Bostwick, M. Giancarli, N. Allegretto, et al. “Blockade of Protease-Activated Receptor-4 (Par4) Provides Robust Antithrombotic Activity with Low Bleeding.” [In eng]. Sci Transl Med 9, no. 371 (Jan 4 2017).

Localisation of Two Bioactive Labdane Diterpenoids in the Peltate Glandular Trichomes of Leonurus japonicus by Laser Microdissection Coupled with UPLC-MS/MS.

Xiao, C. J., Y. C. Liu, S. H. Luo, J. Hua, Y. Liu, and S. H. Li. “Localisation of Two Bioactive Labdane Diterpenoids in the Peltate Glandular Trichomes of Leonurus Japonicus by Laser Microdissection Coupled with Uplc-Ms/Ms.” [In eng]. Phytochem Anal 28, no. 5 (Sep 2017): 404-09.

Phenylsulfonylfuroxan NO-donor phenols: Synthesis and multifunctional activities evaluation.

Xie, Y., Y. Yang, S. Li, Y. Xu, W. Lu, Z. Chen, G. Yang, et al. “Phenylsulfonylfuroxan No-Donor Phenols: Synthesis and Multifunctional Activities Evaluation.” [In eng]. Bioorg Med Chem 25, no. 16 (Aug 15 2017): 4407-13.

Design, synthesis and evaluation of novel 2-amino-3-(naphth-2-yl)propanoic acid derivatives as potent inhibitors of platelet aggregation.

Xie, Z., B. Oscar, L. Zhao, X. Ding, C. Cao, S. Feng, H. Li, et al. “Design, Synthesis and Evaluation of Novel 2-Amino-3-(Naphth-2-Yl)Propanoic Acid Derivatives as Potent Inhibitors of Platelet Aggregation.” [In eng]. Eur J Med Chem 125 (Jan 5 2017): 197-209.

Design, synthesis and biological evaluation of novel 2,3-dihydroquinazolin- 4(1H)-one derivatives as potential fXa inhibitors.

Xing, J., L. Yang, Y. Yang, L. Zhao, Q. Wei, J. Zhang, J. Zhou, and H. Zhang. “Design, Synthesis and Biological Evaluation of Novel 2,3-Dihydroquinazolin- 4(1h)-One Derivatives as Potential Fxa Inhibitors.” [In eng]. Eur J Med Chem 125 (Jan 5 2017): 411-22.

An efficient anticoagulant candidate: Characterization, synthesis and in vivo study of a fondaparinux analogue Rrt1.17.

Zhang, G. Q., H. Jin, Y. Zhao, L. Guo, X. Gao, X. Wang, S. Tie, et al. “An Efficient Anticoagulant Candidate: Characterization, Synthesis and in Vivo Study of a Fondaparinux Analogue Rrt1.17.” [In eng]. Eur J Med Chem 126 (Jan 27 2017): 1039-55.

Sixteen-year nationwide trends in antithrombotic drug use in Denmark and its correlation with landmark studies.

Adelborg, K., E. L. Grove, J. Sundboll, M. Laursen, and M. Schmidt. “Sixteen-Year Nationwide Trends in Antithrombotic Drug Use in Denmark and Its Correlation with Landmark Studies.” [In eng]. Heart 102, no. 23 (Dec 1 2016): 1883-89.

Averrhoa bilimbi Linn.: A review of its ethnomedicinal uses, phytochemistry, and pharmacology.

Alhassan, A. M., and Q. U. Ahmed. “Averrhoa Bilimbi Linn.: A Review of Its Ethnomedicinal Uses, Phytochemistry, and Pharmacology.” [In eng]. J Pharm Bioallied Sci 8, no. 4 (Oct-Dec 2016): 265-71.

Head-to-Head comparison of anti-inflammatory performance of known natural products in vitro.

Allijn, I. E., S. F. Vaessen, L. C. Quarles van Ufford, K. J. Beukelman, M. P. de Winther, G. Storm, and R. M. Schiffelers. “Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products in Vitro.” [In eng]. PLoS One 11, no. 5 (2016): e0155325.

Enantioselective inhibition of Cytochrome P450-mediated drug metabolism by a novel antithrombotic agent, S002-333: Major effect on CYP2B6.

Bhateria, M., R. Ramakrishna, S. K. Puttrevu, A. K. Saxena, and R. S. Bhatta. “Enantioselective Inhibition of Cytochrome P450-Mediated Drug Metabolism by a Novel Antithrombotic Agent, S002-333: Major Effect on Cyp2b6.” [In eng]. Chem Biol Interact 256 (Aug 25 2016): 257-65.

Effect of angioprotective therapy with bioflavonoids on endothelial dysfunction in patients with acute venous thromboses.

Bryushkov, A. Y., P. V. Ershov, N. A. Sergeeva, and V. Y. Bogachev. “[Effect of Angioprotective Therapy with Bioflavonoids on Endothelial Dysfunction in Patients with Acute Venous Thromboses].” [In rus]. Angiol Sosud Khir 22, no. 4 (2016): 102-08.

Evaluating antithrombotic activity of HY023016 on rat hypercoagulable model.

Chen, Q. F., Y. Z. Li, X. H. Wang, Y. R. Su, S. Cui, M. X. Miao, Z. Z. Jiang, et al. “Evaluating Antithrombotic Activity of Hy023016 on Rat Hypercoagulable Model.” [In eng]. Eur J Pharmacol 781 (Jun 15 2016): 190-7.

Comparison of efficacy of different treatments for pulmonary embolism.

Fan, Y., H. Huang, J. Xiong, M. Yang, B. Kong, J. F. Liao, W. W. He, and Z. Q. Wang. “Comparison of Efficacy of Different Treatments for Pulmonary Embolism.” [In eng]. J Huazhong Univ Sci Technolog Med Sci 36, no. 2 (Apr 2016): 254-8.

Comparison of Efficacy and Safety of Left Atrial Appendage Occlusion in Patients Aged < 75 to >= 75 Years.

Freixa, X., S. Gafoor, A. Regueiro, I. Cruz-Gonzalez, S. Shakir, H. Omran, S. Berti, et al. “Comparison of Efficacy and Safety of Left Atrial Appendage Occlusion in Patients Aged <75 to >/= 75 Years.” [In eng]. Am J Cardiol 117, no. 1 (Jan 1 2016): 84-90.

Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation.

Jensen, G. S., C. Drapeau, M. Lenninger, and K. F. Benson. “Clinical Safety of a High Dose of Phycocyanin-Enriched Aqueous Extract from Arthrospira (Spirulina) Platensis: Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation.” [In eng]. J Med Food 19, no. 7 (Jul 2016): 645-53.

Network meta-analysis of efficacy and safety of competitive oral anticoagulants in patients undergoing radiofrequency catheter ablation of atrial fibrillation.

Li, P. J., J. Xiao, Q. Yang, Y. Feng, T. Wang, G. J. Liu, and Z. A. Liang. “Network Meta-Analysis of Efficacy and Safety of Competitive Oral Anticoagulants in Patients Undergoing Radiofrequency Catheter Ablation of Atrial Fibrillation.” [In eng]. J Interv Card Electrophysiol 46, no. 3 (Sep 2016): 213-24.

Over 1-year efficacy and safety of left atrial appendage occlusion versus novel oral anticoagulants for stroke prevention in atrial fibrillation: A systematic review and meta-analysis of randomized controlled trials and observational studies.

Li, X., S. N. Wen, S. N. Li, R. Bai, N. Liu, L. Feng, Y. F. Ruan, et al. “Over 1-Year Efficacy and Safety of Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies.” [In eng]. Heart Rhythm 13, no. 6 (Jun 2016): 1203-14.

Synthesis, in vivo anticoagulant evaluation and molecular docking studies of bicoumarins obtained from furocoumarin peucedanin.

Lipeeva, A. V., M. V. Khvostov, D. S. Baev, M. M. Shakirov, T. G. Tolstikova, and E. E. Shults. “Synthesis, in Vivo Anticoagulant Evaluation and Molecular Docking Studies of Bicoumarins Obtained from Furocoumarin Peucedanin.” [In eng]. Med Chem 12, no. 7 (2016): 674-83.

Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: Allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin.

Mehta, A. Y., B. M. Mohammed, E. J. Martin, D. F. Brophy, D. Gailani, and U. R. Desai. “Allosterism-Based Simultaneous, Dual Anticoagulant and Antiplatelet Action: Allosteric Inhibitor Targeting the Glycoprotein Ibalpha-Binding and Heparin-Binding Site of Thrombin.” [In eng]. J Thromb Haemost 14, no. 4 (Apr 2016): 828-38.

Xylarinase: a novel clot busting enzyme from an endophytic fungus Xylaria curta.

Meshram, V., S. Saxena, and K. Paul. “Xylarinase: A Novel Clot Busting Enzyme from an Endophytic Fungus Xylaria Curta.” [In eng]. J Enzyme Inhib Med Chem 31, no. 6 (Dec 2016): 1502-11.

Synthesis and evaluation of dual antiplatelet activity of bispidine derivatives of N-substituted pyroglutamic acids.

Misra, A., K. S. Anil Kumar, M. Jain, K. Bajaj, S. Shandilya, S. Srivastava, P. Shukla, et al. “Synthesis and Evaluation of Dual Antiplatelet Activity of Bispidine Derivatives of N-Substituted Pyroglutamic Acids.” [In eng]. Eur J Med Chem 110 (Mar 3 2016): 1-12.

Synthesis, structure elucidation, DNA-PK, PI3K, anti-platelet and anti-bacteria activity of linear 5, 6, and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3, 4, 6-substituted-8-morpholino-chromen-oxazine-2,10-dione.

Morrison, R., and J. M. Al-Rawi. “Synthesis, Structure Elucidation, DNA-Pk, Pi3k, Anti-Platelet and Anti-Bacteria Activity of Linear 5, 6, and 10-Substituted-2-Morpholino-Chromen-Oxazine-Dione and Angular 3, 4, 6-Substituted-8-Morpholino-Chromen-Oxazine-2,10-Dione.” [In eng]. J Enzyme Inhib Med Chem 31, no. sup2 (2016): 86-95.

Synthesis, anticlotting and antiplatelet effects of 1,2,3-triazoles derivatives.

Moura, L. A., A. C. de Almeida, A. V. da Silva, V. R. de Souza, V. F. Ferreira, M. V. Menezes, C. R. Kaiser, S. B. Ferreira, and A. L. Fuly. “Synthesis, Anticlotting and Antiplatelet Effects of 1,2,3-Triazoles Derivatives.” [In eng]. Med Chem 12, no. 8 (2016): 733-41.

End-Site-Specific Conjugation of Enoxaparin and Tetradeoxycholic Acid Using Nonenzymatic Glycosylation for Oral Delivery.

Park, J., O. C. Jeon, J. Yun, H. Nam, J. Hwang, T. A. Al-Hilal, K. Kim, and Y. Byun. “End-Site-Specific Conjugation of Enoxaparin and Tetradeoxycholic Acid Using Nonenzymatic Glycosylation for Oral Delivery.” [In eng]. J Med Chem 59, no. 23 (Dec 8 2016): 10520-29.

Polyphenolic-polysaccharide conjugates of Sanguisorba officinalis L. with anticoagulant activity mediated mainly by heparin cofacto.

Pawlaczyk-Graja, I., S. Balicki, R. Ziewiecki, M. Matulova, P. Capek, and R. Gancarz. “Polyphenolic-Polysaccharide Conjugates of Sanguisorba Officinalis L. With Anticoagulant Activity Mediated Mainly by Heparin Cofactor Ii.” [In eng]. Int J Biol Macromol 93, no. Pt A (Dec 2016): 1019-29.

The comparative efficacy of bivalirudin is markedly attenuated by use of radial access: insights from Blue Cross Blue Shield of Michigan Cardiovascular Consortium.

Perdoncin, E., M. Seth, S. Dixon, L. Cannon, A. Khandelwal, A. Riba, S. David, D. Wohns, and H. Gurm. “The Comparative Efficacy of Bivalirudin Is Markedly Attenuated by Use of Radial Access: Insights from Blue Cross Blue Shield of Michigan Cardiovascular Consortium.” [In eng]. Eur Heart J 37, no. 24 (Jun 21 2016): 1902-9.

Comparative Analysis of the Effects of Hydroxysafflor Yellow A and Anhydrosafflor Yellow B in Safflower Series of Herb Pairs Using Prep-HPLC and a Selective Knock-Out Approach.

Qu, C., L. Y. Wang, W. T. Jin, Y. P. Tang, Y. Jin, X. Q. Shi, L. L. Shang, E. X. Shang, and J. A. Duan. “Comparative Analysis of the Effects of Hydroxysafflor Yellow a and Anhydrosafflor Yellow B in Safflower Series of Herb Pairs Using Prep-Hplc and a Selective Knock-out Approach.” [In eng]. Molecules 21, no. 11 (Nov 6 2016).

Diaminopropionic Acid Reinforced Graphene Sponge and Its Use for Hemostasis.

Quan, K., G. Li, L. Tao, Q. Xie, Q. Yuan, and X. Wang. “Diaminopropionic Acid Reinforced Graphene Sponge and Its Use for Hemostasis.” [In eng]. ACS Appl Mater Interfaces 8, no. 12 (Mar 2016): 7666-73.

Antiplatelet pyrazolopyridines derivatives: pharmacological, biochemical and toxicological characterization.

Saito, M. S., A. L. Lourenco, L. R. Dias, A. C. Freitas, M. I. Vitorino, M. G. Albuquerque, C. R. Rodrigues, et al. “Antiplatelet Pyrazolopyridines Derivatives: Pharmacological, Biochemical and Toxicological Characterization.” [In eng]. J Enzyme Inhib Med Chem 31, no. 6 (Dec 2016): 1591-601.

Metabolic profiling of a novel antithrombotic compound, S002-333 and enantiomers: metabolic stability, species comparison and in vitro–in vivo extrapolation.

Saxena, A., G. R. Valicherla, G. K. Jain, R. S. Bhatta, A. K. Saxena, and J. R. Gayen. “Metabolic Profiling of a Novel Antithrombotic Compound, S002-333 and Enantiomers: Metabolic Stability, Species Comparison and in Vitro-in Vivo Extrapolation.” [In eng]. Biopharm Drug Dispos 37, no. 4 (May 2016): 185-99.

Early Experience of Novel Oral Anticoagulants in Catheter Ablation for Atrial Fibrillation: Efficacy and Safety Comparison to Warfarin.

Shin, D. G., T. H. Kim, J. S. Uhm, J. Y. Kim, B. Joung, M. H. Lee, and H. N. Pak. “Early Experience of Novel Oral Anticoagulants in Catheter Ablation for Atrial Fibrillation: Efficacy and Safety Comparison to Warfarin.” [In eng]. Yonsei Med J 57, no. 2 (Mar 2016): 342-9.

A strategic approach for rapid synthesis of gold and silver nanoparticles by Panax ginseng leaves.

Singh, P., Y. J. Kim, and D. C. Yang. “A Strategic Approach for Rapid Synthesis of Gold and Silver Nanoparticles by Panax Ginseng Leaves.” [In eng]. Artif Cells Nanomed Biotechnol 44, no. 8 (Dec 2016): 1949-57.

Design, green synthesis and pharmacological evaluation of novel 5,6-diaryl-1,2,4-triazines bearing 3-morpholinoethylamine moiety as potential antithrombotic agents.

Tamboli, R. S., R. Giridhar, H. P. Gandhi, A. M. Kanhed, H. M. Mande, and M. R. Yadav. “Design, Green Synthesis and Pharmacological Evaluation of Novel 5,6-Diaryl-1,2,4-Triazines Bearing 3-Morpholinoethylamine Moiety as Potential Antithrombotic Agents (.).” [In eng]. J Enzyme Inhib Med Chem 31, no. 5 (Oct 2016): 704-13.

Molecular design, synthesis and anticoagulant activity evaluation of fluorinated dabigatran analogues.

Wang, F., Y. J. Ren, and M. H. Dong. “Molecular Design, Synthesis and Anticoagulant Activity Evaluation of Fluorinated Dabigatran Analogues.” [In eng]. Bioorg Med Chem 24, no. 12 (Jun 15 2016): 2739-53.

Design, synthesis, and structure–activity relationship of novel and effective apixaban derivatives as FXa inhibitors containing 1,2,4-triazole/pyrrole derivatives as P2 binding element.

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In vitro and in vivo characterization of a reversible synthetic heparin analog.

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A novel lead of P-selectin inhibitor: Discovery, synthesis, bioassays and action mechanism.

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G-quadruplex aptamers to human thrombin versus other direct thrombin inhibitors: The focus on mechanism of action and drug efficiency as anticoagulants.

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Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo.

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