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Vitamin D – Effect on Health Issues

Posted January 2, 2012

Influenza pandemics, solar activity cycles, and vitamin D

Health Issue: Influenza

Hayes, D. P. Influenza pandemics, solar activity cycles, and vitamin D. Med Hypotheses 74 (5):831-4.

Improvement in vitamin D deficiency following antiretroviral regime change: Results from the MONET trial

Health Issue: HIV

Fox, J., B. Peters, M. Prakash, J. Arribas, A. Hill, and C. Moecklinghoff. Improvement in vitamin D deficiency following antiretroviral regime change: Results from the MONET trial. AIDS Res Hum Retroviruses 27 (1):29-34.

Immunophenotype of vitamin D receptor polymorphism associated to risk of HIV-1 infection and rate of disease progression

Health Issue: HIV

Torres, C., M. Sanchez de la Torre, C. Garcia-Moruja, A. J. Carrero, M. Trujillo Mdel, J. Fibla, and A. Caruz. Immunophenotype of vitamin D receptor polymorphism associated to risk of HIV-1 infection and rate of disease progression. Curr HIV Res 8 (6):487-92.

Highly prevalent vitamin D deficiency and insufficiency in an urban cohort of HIV-infected men under care

Health Issue: HIV

Wasserman, P., and D. S. Rubin. Highly prevalent vitamin D deficiency and insufficiency in an urban cohort of HIV-infected men under care. AIDS Patient Care STDS 24 (4):223-7.

Decrease of vitamin D concentration in patients with HIV infection on a non nucleoside reverse transcriptase inhibitor-containing regimen

Health Issue: HIV

Conesa-Botella, A., E. Florence, L. Lynen, R. Colebunders, J. Menten, and R. Moreno-Reyes. Decrease of vitamin D concentration in patients with HIV infection on a non nucleoside reverse transcriptase inhibitor-containing regimen. AIDS Res Ther 7:40.

Ample evidence exists from human studies that vitamin D reduces the risk of selected bacterial and viral infections.

Health Issue: Bacterial and Viral Infections

Grant, W. B., M. Goldstein, and L. Mascitelli. Ample evidence exists from human studies that vitamin D reduces the risk of selected bacterial and viral infections. Exp Biol Med (Maywood) 235 (12):1395-6; discussion 1397.

Vitamin D, innate immunity and upper respiratory tract infection

Health Issue: Respiratory Tract Infections

Bartley, J. Vitamin D, innate immunity and upper respiratory tract infection. J Laryngol Otol 124 (5):465-9.

Vitamin D supplementation could reduce the risk of type a influenza infection and subsequent pneumonia

Health Issue: Influenza

Grant, W. B. Vitamin D supplementation could reduce the risk of type A influenza infection and subsequent pneumonia. Pediatr Infect Dis J 29 (10):987.

Vitamin D status of HIV-infected women and its association with hiv disease progression, anemia, and mortality

Health Issue: HIV

Mehta, S., E. Giovannucci, F. M. Mugusi, D. Spiegelman, S. Aboud, E. Hertzmark, G. I. Msamanga, D. Hunter, and W. W. Fawzi. Vitamin D status of HIV-infected women and its association with HIV disease progression, anemia, and mortality. PLoS One 5 (1):e8770.

Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan

Health Issue: Hepatitis B

Huang, Y. W., Y. T. Liao, W. Chen, C. L. Chen, J. T. Hu, C. J. Liu, M. Y. Lai, P. J. Chen, D. S. Chen, S. S. Yang, and J. H. Kao. Vitamin D receptor gene polymorphisms and distinct clinical phenotypes of hepatitis B carriers in Taiwan. Genes Immun 11 (1):87-93.

Vitamin D levels in Norway may be inadequate to reduce risk of breast cancer

Health Issue: Breast Cancer

Grant, W. B., A. Juzeniene, Z. Lagunova, A. C. Porojnicu, and J. E. Moan. Vitamin D levels in Norway may be inadequate to reduce risk of breast cancer. Int J Cancer 128 (9):2249-50.

Vitamin D inadequacy in pregnancy: Biology, outcomes, and interventions

Health Issue: Pregnancy

Dror, D. K., and L. H. Allen. Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions. Nutr Rev 68 (8):465-77.

Vitamin D has a direct immunomodulatory effect on CD8+T cells of patients with early multiple sclerosis and healthy control subjects

Health Issue: Multiple Sclerosis

Lysandropoulos, A. P., E. Jaquiery, S. Jilek, G. Pantaleo, M. Schluep, and R. A. Du Pasquier. Vitamin D has a direct immunomodulatory effect on CD8+ T cells of patients with early multiple sclerosis and healthy control subjects. J Neuroimmunol 233 (1-2):240-4.

Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection

Health Issue: HIV & Diabetes

Szep, Z., G. Guaraldi, S. S. Shah, V. Lo Re, 3rd, S. J. Ratcliffe, G. Orlando, F. Carli, R. Rossi, V. Rochira, and P. Tebas. Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection. AIDS 25 (4):525-9.

Vitamin D deficiency in HIV-infected postmenopausal Hispanic and African-American women

Health Issue: HIV

Stein, E. M., M. T. Yin, D. J. McMahon, A. Shu, C. A. Zhang, D. C. Ferris, I. Colon, J. F. Dobkin, S. M. Hammer, and E. Shane. Vitamin D deficiency in HIV-infected postmenopausal Hispanic and African-American women. Osteoporos Int 22 (2):477-87.

Vitamin D deficiency in HIV-infected patients: Associated with non-nucleoside reverse transcriptase inhibitor or efavirenz use?

Health Issue: HIV

Pasquet, A., N. Viget, F. Ajana, X. de la Tribonniere, S. Dubus, J. Paccou, I. Legroux-Gerot, H. Melliez, B. Cortet, and Y. Yazdanpanah. Vitamin D deficiency in HIV-infected patients: associated with non-nucleoside reverse transcriptase inhibitor or efavirenz use? AIDS 25 (6):873-4.

Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy

Health Issue: Hepatitis C

Lange, C. M., J. Bojunga, E. Ramos-Lopez, M. von Wagner, A. Hassler, J. Vermehren, E. Herrmann, K. Badenhoop, S. Zeuzem, and C. Sarrazin. Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy. J Hepatol 54 (5):887-93.

Vitamin D and tuberculosis

Health Issue: Tuberculosis

Davies, P. Vitamin D and tuberculosis. Am J Respir Crit Care Med 181 (1):94, author reply 95.

Vitamin D and multiple sclerosis: Can vitamin D prevent disease progression?

Health Issue: Multiple Sclerosis

Mehta, B., M. Ramanathan, and B. Weinstock-Guttman. Vitamin D and multiple sclerosis: can vitamin D prevent disease progression? Expert Rev Neurother 11 (4):469-71.

Vitamin D and molecular actions on the immune system: Modulation of innate and autoimmunity

Health Issue: Immune system

Kamen, D. L., and V. Tangpricha. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med (Berl) 88 (5):441-50.

Vitamin D and host resistance to infection? Putting the cart in front of the horse: Authors reply

Health Issue: Immune System

Bruce, D., J. H. Ooi, S. Yu, and M. T. Cantorna. Vitamin D and host resistance to infection? Putting the cart in front of the horse. Exp Biol Med (Maywood) 235 (8):921-7.

The effect of antiretrovirals on vitamin D

Health Issue: HIV

Yin, M., and E. Stein. The effect of antiretrovirals on vitamin D. Clin Infect Dis 52 (3):406-8.

Th17 mediators and vitamin D status in influenza A (H1N1)

Health Issue: Influenza

Krstic, G. Th17 mediators and vitamin D status in influenza A (H1N1). Crit Care 14 (3):417.

Tenofovir-linked hyperparathyroidism is independently associated with the presence of vitamin D deficiency

Health Issue: Hyperthyroidism

Rosenvinge, M. M., K. Gedela, A. J. Copas, A. Wilkinson, C. A. Sheehy, G. Bano, P. E. Hay, M. R. Pakianathan, and S. T. Sadiq. Tenofovir-linked hyperparathyroidism is independently associated with the presence of vitamin D deficiency. J Acquir Immune Defic Syndr 54 (5):496-9.

Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users

Health Issue: Parathyroid Hormone (PTH)

Childs, K. E., S. L. Fishman, C. Constable, J. A. Gutierrez, C. M. Wyatt, D. T. Dieterich, M. P. Mullen, and A. D. Branch. Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users. AIDS Res Hum Retroviruses 26 (8):855-9.

Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren

Health Issue: Influenza

Urashima, M., T. Segawa, M. Okazaki, M. Kurihara, Y. Wada, and H. Ida. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 91 (5):1255-60.

Prevalence of vitamin D deficiency in adult tuberculosis patients at a central hospital in Malawi

Health Issue: Tuberculosis

Banda, R., B. Mhemedi, and T. J. Allain. Prevalence of vitamin D deficiency in adult tuberculosis patients at a central hospital in Malawi. Int J Tuberc Lung Dis 15 (3):408-10.

Pandemic influenza A (H1N1): mandatory vitamin D supplementation?

Health Issue: Influenza

Goldstein, M. R., L. Mascitelli, and F. Pezzetta. Pandemic influenza A (H1N1): mandatory vitamin D supplementation? Med Hypotheses 74 (4):756.

Association between Epstein-Barr virus infection and risk for development of pregnancy-associated breast cancer: Joint effect with vitamin D?

Health Issue: Epstein-Barr Infection/ Breast Cancer

Agborsangaya, C. B., T. Lehtinen, A. T. Toriola, E. Pukkala, H. M. Surcel, R. Tedeschi, and M. Lehtinen. Association between Epstein-Barr virus infection and risk for development of pregnancy-associated breast cancer: joint effect with vitamin D? Eur J Cancer 47 (1):116-20.

Environmental factors in multiple sclerosis: Epstein-Barr virus, vitamin D, and cigarette smoking

Health Issue: Epstein-Barr

Wingerchuk, D. M. Environmental factors in multiple sclerosis: Epstein-Barr virus, vitamin D, and cigarette smoking. Mt Sinai J Med 78 (2):221-30.

Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes

Health Issue: Epstein-Barr

Yenamandra, S. P., U. Hellman, B. Kempkes, S. D. Darekar, S. Petermann, T. Sculley, G. Klein, and E. Kashuba. Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes. Cell Mol Life Sci 67 (24):4249-56.

Latitude and multiple sclerosis prevalence: Vitamin D reduces risk of Epstein-Barr virus infection

Health Issue: Epstein Barr

Grant, W. B. Latitude and multiple sclerosis prevalence: vitamin D reduces risk of Epstein-Barr virus infection. Mult Scler 16 (3):373; author reply 374-5.

Vitamin D Status and Antibody Levels to Common Viruses in Pediatric-Onset Multiple Sclerosis

Health Issue: Mulitple Sclerosis

Mowry, E. M., J. A. James, L. B. Krupp, and E. Waubant. Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis. Mult Scler 17 (6):666-71.

Vitamin D and the anti-viral state

Health Issue: Immune System

Beard, J. A., A. Bearden, and R. Striker. Vitamin D and the anti-viral state. J Clin Virol 50 (3):194-200.

Vitamin D decreases respiratory syncytial virus induction of NF-KappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state

Health Issue: Respiratory Infections

Hansdottir, S., M. M. Monick, N. Lovan, L. Powers, A. Gerke, and G. W. Hunninghake. Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol 184 (2):965-74.

Sun exposure, vitamin D, and risk of hodgkin and non-hodgkin lymphoma

Health Issue: Non-Hodgkin’s Lymphoma

Negri, E. Sun exposure, vitamin D, and risk of Hodgkin and non-Hodgkin lymphoma. Nutr Cancer 62 (7):878-82.

Sun, vitamin D, and cardiovascular disease

Health Issue: Cardiovascular Disease

Zittermann, A., and J. F. Gummert. Sun, vitamin D, and cardiovascular disease. J Photochem Photobiol B 101 (2):124-9.

The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: Secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial

Health Issue: Osteoporosis

Zhou, J., L. J. Zhao, P. Watson, Q. Zhang, and J. M. Lappe. The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial. Nutr Metab (Lond) 7:62.

The effect of various vitamin D supplementation regimens in breast cancer patients

Health Issue: Breast Cancer

Peppone, L. J., A. J. Huston, M. E. Reid, R. N. Rosier, Y. Zakharia, D. L. Trump, K. M. Mustian, M. C. Janelsins, J. Q. Purnell, and G. R. Morrow. The effect of various vitamin D supplementation regimens in breast cancer patients. Breast Cancer Res Treat 127 (1):171-7.

The effects of whole-body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women: A 6-month randomized, controlled trial

Health Issue: Osteoporosis

Verschueren, S. M., A. Bogaerts, C. Delecluse, A. L. Claessens, P. Haentjens, D. Vanderschueren, and S. Boonen. The effects of whole-body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women: a 6-month randomized, controlled trial. J Bone Miner Res 26 (1):42-9.

The roles of ultraviolet-B irradiance, vitamin D, apolipoprotein e epsilon4, and diet in the risk of prostate cancer

Health Issue: Prostate Cancer

Grant, W. B. The roles of ultraviolet-B irradiance, vitamin D, apolipoprotein E epsilon4, and diet in the risk of prostate cancer. Cancer Causes Control 22 (1):157-8.

Vitamin D pathway genes, diet, and risk of renal cell carcinoma

Health Issue: Renal Cell Carcinoma

Karami, S., P. Brennan, M. Navratilova, D. Mates, D. Zaridze, V. Janout, H. Kollarova, V. Bencko, V. Matveev, N. Szesznia-Dabrowska, I. Holcatova, M. Yeager, S. Chanock, N. Rothman, P. Boffetta, W. H. Chow, and L. E. Moore. Vitamin d pathway genes, diet, and risk of renal cell carcinoma. Int J Endocrinol 010:879362.

Vitamin D status and supplementation in pediatric gastrointestinal disease.

Health Issue: Gastrointestinal Disease

O’Malley, T., and R. Heuberger. Vitamin D status and supplementation in pediatric gastrointestinal disease. J Spec Pediatr Nurs 16 (2):140-50.

Vitamin D status relative to diet, lifestyle, injury, and illness in college athletes.

Health Issue: Illness

Halliday, T. M., N. J. Peterson, J. J. Thomas, K. Kleppinger, B. W. Hollis, and D. E. Larson-Meyer. Vitamin D status relative to diet, lifestyle, injury, and illness in college athletes. Med Sci Sports Exerc 43 (2):335-43.

Vitamin D supplementation and fracture risk

Health Issue: Bone Fracture

Bischoff-Ferrari, H. A., B. Dawson-Hughes, and S. J. Whiting. Vitamin D supplementation and fracture risk. Arch Intern Med 171 (3):265; author reply 265-6.

Vitamin D supplementation and regulatory T Cells in apparently healthy subjects: Vitamin D treatment for autoimmune diseases?

Health Issue: Autoimmune Disease

Prietl, B., S. Pilz, M. Wolf, A. Tomaschitz, B. Obermayer-Pietsch, W. Graninger, and T. R. Pieber. Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases? Isr Med Assoc J 12 (3):136-9.

Vitamin D supplementation could reduce risk of sepsis in infants

Health Issue: Sepsis

Grant, W. B. Vitamin D supplementation could reduce risk of sepsis in infants. World J Pediatr 6 (2):185; author reply 185-6.

Vitamin D supplementation in chronic kidney disease: A systematic review and meta-analysis of observational studies and randomized controlled trials

Health Issue: Kidney Disease

Kandula, P., M. Dobre, J. D. Schold, M. J. Schreiber, Jr., R. Mehrotra, and S. D. Navaneethan. Vitamin D supplementation in chronic kidney disease: a systematic review and meta-analysis of observational studies and randomized controlled trials. Clin J Am Soc Nephrol 6 (1):50-62.

Vitamin D supplementation of mother and infant could reduce risk of sepsis in premature infants

Health Issue: Sepsis

Grant, W. B. Vitamin D supplementation of mother and infant could reduce risk of sepsis in premature infants. Early Hum Dev 86 (2):133.

Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?

Health Issue: Inflammation

Hoeck, A. D., and M. L. Pall. Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue? Med Hypotheses 76 (2):208-13.

Effects of vitamin D supplementation on 25-hydroxyvitamin D, high-density lipoprotein cholesterol, and other cardiovascular disease risk markers in subjects with elevated waist circumference.

Health Issue: Cardiovascular Disease

Maki, K. C., M. R. Rubin, L. G. Wong, J. F. McManus, C. D. Jensen, and A. Lawless. Effects of vitamin D supplementation on 25-hydroxyvitamin D, high-density lipoprotein cholesterol, and other cardiovascular disease risk markers in subjects with elevated waist circumference. Int J Food Sci Nutr 62 (4):318-27.

Effects of vitamin D supplementation on blood pressure

Health Issue: Blood Pressure

Wu, S. H., S. C. Ho, and L. Zhong. Effects of vitamin D supplementation on blood pressure. South Med J 103 (8):729-37.

Effects of vitamin D supplementation on bone density in healthy children: Systematic review and meta-analysis

Health Issue: Bone Density

Winzenberg, T., S. Powell, K. A. Shaw, and G. Jones. Effects of vitamin D supplementation on bone density in healthy children: systematic review and meta-analysis. BMJ 342:c7254.

Effects of vitamin D supplementation to children diagnosed with pneumonia in Kabul: A randomised controlled trial

Health Issue: Pneumonia

Manaseki-Holland, S., G. Qader, M. Isaq Masher, J. Bruce, M. Zulf Mughal, D. Chandramohan, and G. Walraven. Effects of vitamin D supplementation to children diagnosed with pneumonia in Kabul: a randomised controlled trial. Trop Med Int Health 15 (10):1148-55.

High-dose oral vitamin D supplementation and risk of falls in older women [2]

Health Issue: Bone Fracture

Prieto-Alhambra, D., A. Judge, and M. Pazianas. High-dose oral vitamin D supplementation and risk of falls in older women. JAMA 304 (8):854-5; author reply 856-7.

High-dose oral vitamin D supplementation and risk of falls in older women [3]

Health Issue: Bone Fracture

Gallieni, M. High-dose oral vitamin D supplementation and risk of falls in older women. JAMA 304 (8):855; author reply 856-7.

High-dose oral vitamin D supplementation and risk of falls in older women [4]

Health Issue: Bone Fracture

Malgarini, R. B., and G. Pimpinella. High-dose oral vitamin D supplementation and risk of falls in older women. JAMA 304 (8):855-6; author reply 856-7.

Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies.

Health Issue: Bone Fracture

Lai, J. K., R. M. Lucas, M. S. Clements, A. W. Roddam, and E. Banks. Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies. BMC Public Health 10:331.

Joint effects of dietary vitamin d and sun exposure on breast cancer risk: Results from the French E3N cohort

Health Issue: Breast Cancer

Engel, P., G. Fagherazzi, S. Mesrine, M. C. Boutron-Ruault, and F. Clavel-Chapelon. Joint effects of dietary vitamin D and sun exposure on breast cancer risk: results from the French E3N cohort. Cancer Epidemiol Biomarkers Prev 20 (1):187-98.

Letter by Begg et al regarding article, ‘the effects of vitamin D supplementation on physical function and quality of life in older heart failure patients: A randomized controlled trial’

Health Issue: Heart Failure

Begg, G. A., J. G. Cleland, and K. K. Witte. Letter by Begg et al regarding article, “The effects of vitamin d supplementation on physical function and quality of life in older heart failure patients: a randomized controlled trial”. Circ Heart Fail 3 (4):e24; author reply e25.

No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D for 1 year.

Health Issue: Cardiovascular Disease

Jorde, R., M. Sneve, P. Torjesen, and Y. Figenschau. No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med 267 (5):462-72.

Nutritional status of vitamin D and the effect of vitamin D supplementation in Korean breast-fed infants.

Health Issue: Bone Density

Kim, M. J., B. Na, S. J. No, H. S. Han, E. H. Jeong, W. Lee, Y. Han, and T. Hyeun. Nutritional status of vitamin D and the effect of vitamin D supplementation in Korean breast-fed infants. J Korean Med Sci 25 (1):83-9.

One-year effects of vitamin d and calcium supplementation on chronic periodontitis.

Health Issue: Periodontitis

Garcia, M. N., C. F. Hildebolt, D. D. Miley, D. A. Dixon, R. A. Couture, C. L. Spearie, E. M. Langenwalter, W. D. Shannon, E. Deych, C. Mueller, and R. Civitelli. One-year effects of vitamin D and calcium supplementation on chronic periodontitis. J Periodontol 82 (1):25-32.

Relationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: A meta-regression

Health Issue: Bone Fracture

Rabenda, V., O. Bruyere, and J. Y. Reginster. Relationship between bone mineral density changes and risk of fractures among patients receiving calcium with or without vitamin D supplementation: a meta-regression. Osteoporos Int 22 (3):893-901.

Response to vitamin D supplementation during antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr virus reactivation

Health Issue: Epstein-Barr

Zwart, S. R., S. K. Mehta, R. Ploutz-Snyder, Y. Bourbeau, J. P. Locke, D. L. Pierson, and S. M. Smith. Response to vitamin D supplementation during Antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr Virus Reactivation. J Nutr 141 (4):692-7.

Safety and T cell modulating effects of high dose vitamin d(3) supplementation in multiple sclerosis.

Health Issue: Multiple Sclerosis

Smolders, J., E. Peelen, M. Thewissen, J. W. Cohen Tervaert, P. Menheere, R. Hupperts, and J. Damoiseaux. Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis. PLoS One 5 (12):e15235.

Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: Is it time to routinely supplement patients with SLE with vitamin D?

Health Issue: Arthritis/Rheumatism

Amital, H., Z. Szekanecz, G. Szucs, K. Danko, E. Nagy, T. Csepany, E. Kiss, J. Rovensky, A. Tuchynova, D. Kozakova, A. Doria, N. Corocher, N. Agmon-Levin, V. Barak, H. Orbach, G. Zandman-Goddard, and Y. Shoenfeld. Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D? Ann Rheum Dis 69 (6):1155-7.

Sun exposure and vitamin D are independent risk factors for CNS demyelination

Health Issue: CNS Demyelination

Lucas, R. M., A. L. Ponsonby, K. Dear, P. C. Valery, M. P. Pender, B. V. Taylor, T. J. Kilpatrick, T. Dwyer, A. Coulthard, C. Chapman, I. van der Mei, D. Williams, and A. J. McMichael. Sun exposure and vitamin D are independent risk factors for CNS demyelination. Neurology 76 (6):540-8.

Sun exposure, vitamin D and age at disease onset in relapsing multiple sclerosis

Health Issue: Multiple Sclerosis

McDowell, T. Y., S. Amr, W. J. Culpepper, P. Langenberg, W. Royal, C. Bever, and D. D. Bradham. Sun exposure, vitamin D and age at disease onset in relapsing multiple sclerosis. Neuroepidemiology 36 (1):39-45.

A Randomized Clinical Trial of the Effects of Supplemental Calcium and Vitamin D3 on Markers of Their Metabolism in Normal Mucosa of Colorectal Adenoma Patients

Health Issue: Colorectal Adenoma

Ahearn, T. U., M. L. McCullough, W. D. Flanders, Q. Long, E. Sidelnikov, V. Fedirko, C. R. Daniel, R. E. Rutherford, A. Shaukat, and R. M. Bostick. A randomized clinical trial of the effects of supplemental calcium and vitamin D3 on markers of their metabolism in normal mucosa of colorectal adenoma patients. Cancer Res 71 (2):413-23.

Are commonly recommended dosages for vitamin D supplementation too low? Vitamin D status and effects of supplementation on serum 25-hydroxyvitamin D levels-an observational study during clinical practice conditions

Health Issue: Osteoporosis

Leidig-Bruckner, G., H. J. Roth, T. Bruckner, A. Lorenz, F. Raue, and K. Frank-Raue. Are commonly recommended dosages for vitamin D supplementation too low? Vitamin D status and effects of supplementation on serum 25-hydroxyvitamin D levels–an observational study during clinical practice conditions. Osteoporos Int 22 (1):231-40.

Benefit-risk assessment of vitamin D supplementation.

Health Issue: Bone Fractures

Bischoff-Ferrari, H. A., A. Shao, B. Dawson-Hughes, J. Hathcock, E. Giovannucci, and W. C. Willett. Benefit-risk assessment of vitamin D supplementation. Osteoporos Int 21 (7):1121-32.

Calcium plus vitamin D supplementation has limited effects on femoral geometric strength in older postmenopausal women: The Women’s Health initiative

Health Issue: Bone Fracture

Jackson, R. D., N. C. Wright, T. J. Beck, D. Sherrill, J. A. Cauley, C. E. Lewis, A. Z. LaCroix, M. S. LeBoff, S. Going, T. Bassford, and Z. Chen. Calcium plus vitamin D supplementation has limited effects on femoral geometric strength in older postmenopausal women: the Women’s Health Initiative. Calcif Tissue Int 88 (3):198-208.

Calcium supplements with or without vitamin D and risk of cardiovascular events: Reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis

Health Issue: Cardiovascular Disease

Bolland, M. J., A. Grey, A. Avenell, G. D. Gamble, and I. R. Reid. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ 342:d2040.

Changes in balance, functional performance and fall risk following whole body vibration training and vitamin D supplementation in institutionalized elderly women. A 6 month randomized controlled trial

Health Issue: Balance

Bogaerts, A., C. Delecluse, S. Boonen, A. L. Claessens, K. Milisen, and S. M. Verschueren. Changes in balance, functional performance and fall risk following whole body vibration training and vitamin D supplementation in institutionalized elderly women. A 6 month randomized controlled trial. Gait Posture 33 (3):466-72.

Children and adolescents with severe mental illness need vitamin D supplementation regardless of disease or treatment

Health Issue: Mental Illness

Bonnot, O., R. Inaoui, M. Raffin-Viard, N. Bodeau, C. Coussieu, and D. Cohen. Children and adolescents with severe mental illness need vitamin D supplementation regardless of disease or treatment. J Child Adolesc Psychopharmacol 21 (2):157-61.

Do calcium plus vitamin D supplements increase cardiovascular risk? Insufficient evidence is available to support or refute the association

Health Issue: Cardiovascular Disease

Abrahamsen, B., and O. Sahota. Do calcium plus vitamin D supplements increase cardiovascular risk? BMJ 342:d2080.

Does daily vitamin D 800 IU and calcium 1000 mg supplementation decrease the risk of falling in ambulatory women aged 65-71 years? A 3-year randomized population-based trial (OSTPRE-FPS)

Health Issue: Balance

Karkkainen, M. K., M. Tuppurainen, K. Salovaara, L. Sandini, T. Rikkonen, J. Sirola, R. Honkanen, J. Arokoski, E. Alhava, and H. Kroger. Does daily vitamin D 800 IU and calcium 1000 mg supplementation decrease the risk of falling in ambulatory women aged 65-71 years? A 3-year randomized population-based trial (OSTPRE-FPS). Maturitas 65 (4):359-65.

Does inconclusive evidence for vitamin D supplementation to reduce risk for cardiovascular disease warrant pessimism?

Health Issue: Cardiovascular Disease

Grant, W. B. Does inconclusive evidence for vitamin D supplementation to reduce risk for cardiovascular disease warrant pessimism? Ann Intern Med 153 (3):209; author reply 209-10.

Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids: results from the Women’s Health Initiative.

Health Issue: Cardiovascular Disease

Rajpathak, S. N., X. Xue, S. Wassertheil-Smoller, L. Van Horn, J. G. Robinson, S. Liu, M. Allison, L. W. Martin, G. Y. Ho, and T. E. Rohan. Effect of 5 y of calcium plus vitamin D supplementation on change in circulating lipids: results from the Women’s Health Initiative. Am J Clin Nutr 91 (4):894-9.

Effect of calcium and vitamin D supplementation on bone mineral density in women aged 65-71 years: A 3-year randomized population-based trial (OSTPRE-FPS)

Health Issue: Bone Density

Karkkainen, M., M. Tuppurainen, K. Salovaara, L. Sandini, T. Rikkonen, J. Sirola, R. Honkanen, J. Jurvelin, E. Alhava, and H. Kroger. Effect of calcium and vitamin D supplementation on bone mineral density in women aged 65-71 years: a 3-year randomized population-based trial (OSTPRE-FPS). Osteoporos Int 21 (12):2047-55.

Effect of vitamin D supplementation on muscle strength: A systematic review and meta-analysis

Health Issue: Muscle

Stockton, K. A., K. Mengersen, J. D. Paratz, D. Kandiah, and K. L. Bennell. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int 22 (3):859-71.

Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer

Health Issue: Joint Pain/Fatigue

Khan, Q. J., P. S. Reddy, B. F. Kimler, P. Sharma, S. E. Baxa, A. P. O’Dea, J. R. Klemp, and C. J. Fabian. Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer. Breast Cancer Res Treat 119 (1):111-8.

Effect of vitamin D supplementation on testosterone levels in men

Health Issue: Testosterone Levels

Pilz, S., S. Frisch, H. Koertke, J. Kuhn, J. Dreier, B. Obermayer-Pietsch, E. Wehr, and A. Zittermann. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res 43 (3):223-5.

Developmental vitamin D deficiency and risk of schizophrenia: A 10-year update

Health Issue: Schizophrenia

McGrath, J. J., T. H. Burne, F. Feron, A. Mackay-Sim, and D. W. Eyles. Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update. Schizophr Bull 36 (6):1073-8.

Desquamative inflammatory vaginitis as a manifestation of vitamin D deficiency associated with Crohn disease: case reports and review of the literature.

Health Issue: Inflammatory Vaginitis

Peacocke, M., E. Djurkinak, H. C. Tsou, and S. Thys-Jacobs. Desquamative inflammatory vaginitis as a manifestation of vitamin D deficiency associated with Crohn disease: case reports and review of the literature. Cutis 86 (1):39-46.

Could combating vitamin D deficiency reduce the incidence of autoimmune disease?

Health Issue: Autoimmune Disease

Kinder, B. W., and J. T. Hagaman. Could combating vitamin D deficiency reduce the incidence of autoimmune disease? Expert Rev Clin Immunol 7 (3):255-7.

Benefits of sunlight: Vitamin D deficiency might increase the risk of sudden unexpected death in epilepsy

Health Issue: Epilepsy

Scorza, F. A., M. Albuquerque, R. M. Arida, V. C. Terra, H. R. Machado, and E. A. Cavalheiro. Benefits of sunlight: vitamin D deficiency might increase the risk of sudden unexpected death in epilepsy. Med Hypotheses 74 (1):158-61.

A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia

Health Issue: Preeclampsia

Baker, A. M., S. Haeri, C. A. Camargo, Jr., J. A. Espinola, and A. M. Stuebe. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab 95 (11):5105-9.

We thought everything had been said about vitamin D, but deficiency still exists and it is not only bone effects .

Health Issue: Bone effects

Mallet, E. [We thought everything had been said about vitamin D, but deficiency still exists and it is not only bone effects]. Arch Pediatr 17 (6):810-1.

Vitamin D deficiency in kidney failure. Risk factor for cardiovascular disease .

Health Issue: Kidney Failure/Cardiovascular Disease

Ohman, K., T. Larsson, and J. Spaak. [Vitamin D deficiency in kidney failure. Risk factor for cardiovascular disease]. Lakartidningen 107 (46):2884-7.

Vitamin D deficiency and cardiovascular diseases

Health Issue: Cardiovascular Disease

Mascitelli, L., M. R. Goldstein, and F. Pezzetta. [Vitamin D deficiency and cardiovascular diseases]. Recenti Prog Med 101 (5):202-11.

Effect of vitamin D deficiency on cardiovascular risk .

Health Issue: Cardiovasculr Disease

Cormier, C., M. Courbebaisse, E. Maury, E. Thervet, and J. C. Souberbielle. [Effect of vitamin D deficiency on cardiovascular risk]. J Mal Vasc 35 (4):235-41.

Relation of vitamin d deficiency to cardiovascular disease.

Health Issue: Cardiovascular Disease

Mullie, P., and P. Autier. Relation of vitamin d deficiency to cardiovascular disease. Am J Cardiol 107 (6):956; author reply 956-7.

Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population.

Health Issue: Cardiovascular Disease

Anderson, J. L., H. T. May, B. D. Horne, T. L. Bair, N. L. Hall, J. F. Carlquist, D. L. Lappe, and J. B. Muhlestein. Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population. Am J Cardiol 106 (7):963-8.

Protean manifestations of vitamin D deficiency, part 3: Association with cardiovascular disease and disorders of the central and peripheral nervous systems

Health Issue: Cardiovascular Disease/Peripheral& Central Nervous System Disorders

Bell, D. S. Protean manifestations of vitamin D deficiency, part 3: association with cardiovascular disease and disorders of the central and peripheral nervous systems. South Med J 104 (5):340-4.

Protean manifestations of vitamin D deficiency, part 2: Deficiency and its association with autoimmune disease, cancer, infection, asthma, dermopathies, insulin resistance, and type 2 diabetes

Health Issue: Autoimmune Disease

Bell, D. S. Protean manifestations of vitamin D deficiency, part 2: deficiency and its association with autoimmune disease, cancer, infection, asthma, dermopathies, insulin resistance, and type 2 diabetes. South Med J 104 (5):335-9.

Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity

Health Issue: Rheumatoid Arthritis

Kerr, G. S., I. Sabahi, J. S. Richards, L. Caplan, G. W. Cannon, A. Reimold, G. M. Thiele, D. Johnson, and T. R. Mikuls. Prevalence of vitamin D insufficiency/deficiency in rheumatoid arthritis and associations with disease severity and activity. J Rheumatol 38 (1):53-9.

Prevalence of vitamin D deficiency in chronic liver disease

Health Issue: Liver Disease

Arteh, J., S. Narra, and S. Nair. Prevalence of vitamin D deficiency in chronic liver disease. Dig Dis Sci 55 (9):2624-8.

Prevalence of vitamin D deficiency in adults with sickle cell disease

Health Issue: Sickle Cell Disease

Goodman, B. M., 3rd, N. Artz, B. Radford, and I. A. Chen. Prevalence of vitamin D deficiency in adults with sickle cell disease. J Natl Med Assoc 102 (4):332-5.

Is vitamin D deficiency a risk factor for ischemic heart disease in patients with established cardiovascular disease? 10-year follow-up of the Nova Scotia Health Survey

Health Issue: Cardiovascular Disease

Wasson, L. T., D. Shimbo, M. R. Rubin, J. A. Shaffer, J. E. Schwartz, and K. W. Davidson. Is vitamin D deficiency a risk factor for ischemic heart disease in patients with established cardiovascular disease? 10-year follow-up of the Nova Scotia Health Survey. Int J Cardiol 148 (3):387-9.

Incidence and risk factors of vitamin D deficiency in critically ill patients: Results from a prospective observational study

Health Issue: Inflammation

Lucidarme, O., E. Messai, T. Mazzoni, M. Arcade, and D. du Cheyron. Incidence and risk factors of vitamin D deficiency in critically ill patients: results from a prospective observational study. Intensive Care Med 36 (9):1609-11.

Impaired regulatory T-cell homeostasis due to vitamin D deficiency in undifferentiated connective tissue disease

Health Issue: Immune System

Zold, E., P. Szodoray, J. Kappelmayer, J. Gaal, L. Csathy, S. Barath, E. Gyimesi, A. Hajas, M. Zeher, G. Szegedi, and E. Bodolay. Impaired regulatory T-cell homeostasis due to vitamin D deficiency in undifferentiated connective tissue disease. Scand J Rheumatol 39 (6):490-7.

Extra-skeletal effects of vitamin D deficiency in chronic kidney disease

Health Issue: Kidney Disease

Chonchol, M., J. Kendrick, and G. Targher. Extra-skeletal effects of vitamin D deficiency in chronic kidney disease. Ann Med 43 (4):273-82.

Effect of vitamin D deficiency on cardiovascular risk

Health Issue: Cardiovascular Disease

Cormier, C., M. Courbebaisse, E. Maury, E. Thervet, and J. C. Souberbielle. [Effect of vitamin D deficiency on cardiovascular risk]. J Mal Vasc 35 (4):235-41.

Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D-deficient Asian Indians: A randomized, controlled trial

Health Issue: Muscle Strength

Gupta, R., U. Sharma, N. Gupta, M. Kalaivani, U. Singh, R. Guleria, N. R. Jagannathan, and R. Goswami. Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D-deficient Asian Indians: a randomized, controlled trial. Clin Endocrinol (Oxf) 73 (4):445-51.

Does vitamin D deficiency contribute to increased rates of cardiovascular disease and type 2 diabetes in African Americans?

Health Issue: Cardiovascular Disease

Harris, S. S. Does vitamin D deficiency contribute to increased rates of cardiovascular disease and type 2 diabetes in African Americans? Am J Clin Nutr 93 (5):1175S-8S.

Disease-specific definitions of vitamin D deficiency need to be established in autoimmune and non-autoimmune chronic diseases: a retrospective comparison of three chronic diseases.

Health Issue: Rheumoatoid Arthritis/Diabetes/lupus

Broder, A. R., J. N. Tobin, and C. Putterman. Disease-specific definitions of vitamin D deficiency need to be established in autoimmune and non-autoimmune chronic diseases: a retrospective comparison of three chronic diseases. Arthritis Res Ther 12 (5):R191.

Vitamin d deficiency and chronic obstructive pulmonary disease a vicious circle.

Health Issue: COPD

Janssens, W., C. Mathieu, S. Boonen, and M. Decramer. Vitamin D deficiency and chronic obstructive pulmonary disease: a vicious circle. Vitam Horm 86:379-99.

Vitamin D: extent of deficiency, effect on muscle function, bone health, performance, and injury prevention.

Health Issue: Muskuloskeletal

Udowenko, M., and T. Trojian. Vitamin D: extent of deficiency, effect on muscle function, bone health, performance, and injury prevention. Conn Med 74 (8):477-80.

Vitamin D deficiency: An increasing concern in peripheral arterial disease

Health Issue: Peripheral Artery Disease

Gaddipati, V. C., R. Kuriacose, R. Copeland, B. A. Bailey, and A. N. Peiris. Vitamin D deficiency: an increasing concern in peripheral arterial disease. J Am Med Dir Assoc 11 (5):308-11.

Vitamin D deficiency prevalence and cardiovascular risk in Israel

Health Issue: Cardiovascular Disease

Steinvil, A., E. Leshem-Rubinow, S. Berliner, D. Justo, T. Finn, M. Ish-shalom, E. Y. Birati, V. Shalev, B. Sheinberg, and O. Rogowski. Vitamin D deficiency prevalence and cardiovascular risk in Israel. Eur J Clin Invest 41 (3):263-8.

Vitamin D deficiency is common in patients with RA and linked to disease activity, but circulating levels are unaffected by TNFalpha blockade: Results from a prospective cohort study

Health Issue: Rheumatoid Arthritis

Welsh, P., M. J. Peters, I. B. McInnes, W. F. Lems, P. T. Lips, G. McKellar, S. Knox, A. Michael Wallace, B. A. Dijkmans, M. T. Nurmohamed, and N. Sattar. Vitamin D deficiency is common in patients with RA and linked to disease activity, but circulating levels are unaffected by TNFalpha blockade: results from a prospective cohort study. Ann Rheum Dis 70 (6):1165-7.

Vitamin D deficiency in rheumatoid arthritis: Prevalence, determinants and associations with disease activity and disability

Health Issue: Rheumatoid Arthritis

Rossini, M., S. Maddali Bongi, G. La Montagna, G. Minisola, N. Malavolta, L. Bernini, E. Cacace, L. Sinigaglia, O. Di Munno, and S. Adami. Vitamin D deficiency in rheumatoid arthritis: prevalence, determinants and associations with disease activity and disability. Arthritis Res Ther 12 (6):R216.

Vitamin D deficiency in patients with inflammatory bowel disease: Association with disease activity and quality of life

Health Issue: Inflammatory Bowel disease

Ulitsky, A., A. N. Ananthakrishnan, A. Naik, S. Skaros, Y. Zadvornova, D. G. Binion, and M. Issa. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr 35 (3):308-16.

Vitamin D deficiency in children with inflammatory bowel disease

Health Issue: Inflammatory Bowel Disease

Levin, A. D., V. Wadhera, S. T. Leach, H. J. Woodhead, D. A. Lemberg, A. C. Mendoza-Cruz, and A. S. Day. Vitamin D deficiency in children with inflammatory bowel disease. Dig Dis Sci 56 (3):830-6.

Vitamin D deficiency in HIV-infected individuals: one more risk factor for bone loss and cardiovascular disease?

Health Issue: Cardiovascular Disease/HIV

Conrado, T., B. Miranda-Filho Dde, and F. Bandeira. Vitamin D deficiency in HIV-infected individuals: one more risk factor for bone loss and cardiovascular disease? Arq Bras Endocrinol Metabol 54 (2):118-22.

Vitamin D deficiency and toxicity in chronic kidney disease: In search of the therapeutic window

Health Issue: Kidney Disease

Querfeld, U., and R. H. Mak. Vitamin D deficiency and toxicity in chronic kidney disease: in search of the therapeutic window. Pediatr Nephrol 25 (12):2413-30.

Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases

Health Issue: Lung Disease

Hagaman, J. T., R. J. Panos, F. X. McCormack, C. V. Thakar, K. A. Wikenheiser-Brokamp, R. T. Shipley, and B. W. Kinder. Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases. Chest 139 (2):353-60.

Vitamin D deficiency and myocardial diseases.

Health Issue: Myocardial Disease

Pilz, S., A. Tomaschitz, C. Drechsler, J. M. Dekker, and W. Marz. Vitamin D deficiency and myocardial diseases. Mol Nutr Food Res 54 (8):1103-13.

Vitamin D deficiency and liver disease

Health Issue: Liver Disease

Nair, S. Vitamin d deficiency and liver disease. Gastroenterol Hepatol (N Y) 6 (8):491-3.

Vitamin D deficiency and connective tissue disease.

Health Issue: Connective Tissue Disease

Zold, E., Z. Barta, and E. Bodolay. Vitamin D deficiency and connective tissue disease. Vitam Horm 86:261-86.

Vitamin D deficiency and chronic pain in sickle cell disease

Health Issue: Chronic Pain

Osunkwo, I., E. I. Hodgman, K. Cherry, C. Dampier, J. Eckman, T. R. Ziegler, S. Ofori-Acquah, and V. Tangpricha. Vitamin D deficiency and chronic pain in sickle cell disease. Br J Haematol 153 (4):538-40.

Vitamin D deficiency and cardiovascular disease: Is there a role for vitamin D therapy in heart failure?

Health Issue: Cardiovascular Disease

Lee, W., and P. M. Kang. Vitamin D deficiency and cardiovascular disease: Is there a role for vitamin D therapy in heart failure? Curr Opin Investig Drugs 11 (3):309-14.

Vitamin D deficiency and anemia in early chronic kidney disease

Health Issue: Kidney Disease

Patel, N. M., O. M. Gutierrez, D. L. Andress, D. W. Coyne, A. Levin, and M. Wolf. Vitamin D deficiency and anemia in early chronic kidney disease. Kidney Int 77 (8):715-20.

Vitamin D deficiency & cardiovascular disease.

Health Issue: Cardiovascular Disease

Sarkinen, B. E. Vitamin D deficiency & cardiovascular disease. Nurse Pract 36 (3):46-53.

Treating vitamin D deficiency (VDD) can also play a role in fight against chronic diseases

Health Issue: Chronic Disease

Khan, A. H. Treating vitamin D deficiency (VDD) can also play a role in fight against chronic diseases. J Pak Med Assoc 60 (2):158-9.

The impact of vitamin D deficiency on diabetes and cardiovascular risk

Health Issue: Cardiovascular Disease/Diabetes

Baz-Hecht, M., and A. B. Goldfine. The impact of vitamin D deficiency on diabetes and cardiovascular risk. Curr Opin Endocrinol Diabetes Obes 17 (2):113-9.