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Prostate Cancer – Alternative Treatment – Update 1

Posted April 27, 2017

A high-fat diet containing lard accelerates prostate cancer progression and reduces survival rate in mice: possible contribution of adipose tissue-derived cytokines.

Alternative Treatment/Prevention: Diet (Fat consumption)

Cho, H. J., G. T. Kwon, H. Park, H. Song, K. W. Lee, J. I. Kim, and J. H. Park. “A High-Fat Diet Containing Lard Accelerates Prostate Cancer Progression and Reduces Survival Rate in Mice: Possible Contribution of Adipose Tissue-Derived Cytokines.” [In eng]. Nutrients 7, no. 4 (Apr 09 2015): 2539-61.

A phase I study of muscadine grape skin extract in men with biochemically recurrent prostate cancer: Safety, tolerability, and dose determination.

Alternative Treatment/Prevention: Muscadine grape skin extract

Paller, C. J., M. A. Rudek, X. C. Zhou, W. D. Wagner, T. S. Hudson, N. Anders, H. J. Hammers, et al. “A Phase I Study of Muscadine Grape Skin Extract in Men with Biochemically Recurrent Prostate Cancer: Safety, Tolerability, and Dose Determination.” [In eng]. Prostate 75, no. 14 (Oct 2015): 1518-25.

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer.

Alternative Treatment/Prevention: Broccoli sprout extract

Alumkal, J. J., R. Slottke, J. Schwartzman, G. Cherala, M. Munar, J. N. Graff, T. M. Beer, et al. “A Phase Ii Study of Sulforaphane-Rich Broccoli Sprout Extracts in Men with Recurrent Prostate Cancer.” [In eng]. Invest New Drugs 33, no. 2 (Apr 2015): 480-9.

A Phase II trial of a combination herbal supplement for men with biochemically recurrent prostate cancer.

Alternative Treatment/Prevention: Herbal Medicine

Dorff, T. B., S. Groshen, D. D. Tsao-Wei, S. Xiong, M. E. Gross, N. Vogelzang, D. I. Quinn, and J. K. Pinski. “A Phase Ii Trial of a Combination Herbal Supplement for Men with Biochemically Recurrent Prostate Cancer.” [In eng]. Prostate Cancer Prostatic Dis 17, no. 4 (Dec 2014): 359-65.

A randomised controlled trial to evaluate the efficacy of a 6-month dietary and physical activity intervention for patients receiving androgen deprivation therapy for prostate cancer.

Alternative Treatment/Prevention: Exercise, Diet

O’Neill, R. F., F. Haseen, L. J. Murray, J. M. O’Sullivan, and M. M. Cantwell. “A Randomised Controlled Trial to Evaluate the Efficacy of a 6-Month Dietary and Physical Activity Intervention for Patients Receiving Androgen Deprivation Therapy for Prostate Cancer.” [In eng]. J Cancer Surviv 9, no. 3 (Sep 2015): 431-40.

A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer.

Alternative Treatment/Prevention: Pomegranate extract

Paller, C. J., X. Ye, P. J. Wozniak, B. K. Gillespie, P. R. Sieber, R. H. Greengold, B. R. Stockton, et al. “A Randomized Phase Ii Study of Pomegranate Extract for Men with Rising Psa Following Initial Therapy for Localized Prostate Cancer.” [In eng]. Prostate Cancer Prostatic Dis 16, no. 1 (Mar 2013): 50-5.

A randomized trial of diet in men with early stage prostate cancer on active surveillance: rationale and design of the Men’s Eating and Living (MEAL) Study (CALGB 70807 [Alliance]).

Alternative Treatment/Prevention: Diet

Parsons, J. K., J. P. Pierce, J. Mohler, E. Paskett, S. H. Jung, P. Humphrey, J. R. Taylor, et al. “A Randomized Trial of Diet in Men with Early Stage Prostate Cancer on Active Surveillance: Rationale and Design of the Men’s Eating and Living (Meal) Study (Calgb 70807 [Alliance]).” [In eng]. Contemp Clin Trials 38, no. 2 (Jul 2014): 198-203.

A randomized, double-blind, placebo-controlled study of the effects of pomegranate extract on rising PSA levels in men following primary therapy for prostate cancer.

Alternative Treatment/Prevention: Pomegranate extract

Pantuck, A. J., C. A. Pettaway, R. Dreicer, J. Corman, A. Katz, A. Ho, W. Aronson, et al. “A Randomized, Double-Blind, Placebo-Controlled Study of the Effects of Pomegranate Extract on Rising Psa Levels in Men Following Primary Therapy for Prostate Cancer.” [In eng]. Prostate Cancer Prostatic Dis 18, no. 3 (Sep 2015): 242-8.

A study of caloric restriction versus standard diet in overweight men with newly diagnosed prostate cancer: a randomized controlled trial.

Alternative Treatment/Prevention: Diet

Wright, J. L., S. Plymate, A. D’Oria-Cameron, C. Bain, K. Haugk, L. Xiao, D. W. Lin, J. L. Stanford, and A. McTiernan. “A Study of Caloric Restriction Versus Standard Diet in Overweight Men with Newly Diagnosed Prostate Cancer: A Randomized Controlled Trial.” [In eng]. Prostate 73, no. 12 (Sep 2013): 1345-51.

Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction.

Alternative Treatment/Prevention: Black tea extract

Sun, S., S. Pan, A. Miao, C. Ling, S. Pang, J. Tang, D. Chen, and C. Zhao. “Active Extracts of Black Tea (Camellia Sinensis) Induce Apoptosis of Pc-3 Prostate Cancer Cells Via Mitochondrial Dysfunction.” [In eng]. Oncol Rep 30, no. 2 (Aug 2013): 763-72.

Adherence to Dietary and Lifestyle Recommendations and Prostate Cancer Risk in the Prostate Testing for Cancer and Treatment (ProtecT) Trial.

Alternative Treatment/Prevention: Diet

Er, V., J. A. Lane, R. M. Martin, P. Emmett, R. Gilbert, K. N. Avery, E. Walsh, et al. “Adherence to Dietary and Lifestyle Recommendations and Prostate Cancer Risk in the Prostate Testing for Cancer and Treatment (Protect) Trial.” [In eng]. Cancer Epidemiol Biomarkers Prev 23, no. 10 (Oct 2014): 2066-77.

Anti-Androgenic Activity of Icarisid II from Epimedium Herb in Prostate Cancer LNCaP Cells.

Alternative Treatment/Prevention: Epimedium herb extract

Miura, Y., M. Oyama, K. Iguchi, T. Ito, M. Baba, Y. Shikama, S. Usui, et al. “Anti-Androgenic Activity of Icarisid Ii from Epimedium Herb in Prostate Cancer Lncap Cells.” [In eng]. J Nutr Sci Vitaminol (Tokyo) 61, no. 2 (2015): 201-4.

Antioxidant, antiangiogenic and antiproliferative activities of root methanol extract of Calliandra portoricensis in human prostate cancer cells.

Alternative Treatment/Prevention: Calliandra portoricensis root extract

Adaramoye, O., B. Erguen, O. Oyebode, B. Nitzsche, M. Hopfner, K. Jung, and A. Rabien. “Antioxidant, Antiangiogenic and Antiproliferative Activities of Root Methanol Extract of Calliandra Portoricensis in Human Prostate Cancer Cells.” [In eng]. J Integr Med 13, no. 3 (May 2015): 185-93.

Antiproliferative Activity of the Dietary Isothiocyanate Erucin, a Bioactive Compound from Cruciferous Vegetables, on Human Prostate Cancer Cells.

Alternative Treatment/Prevention: Diet (Isothiocyanate Erucin from Cruciferous Vegetables)

Melchini, A., M. H. Traka, S. Catania, N. Miceli, M. F. Taviano, P. Maimone, M. Francisco, R. F. Mithen, and C. Costa. “Antiproliferative Activity of the Dietary Isothiocyanate Erucin, a Bioactive Compound from Cruciferous Vegetables, on Human Prostate Cancer Cells.” [In eng]. Nutr Cancer 65, no. 1 (2013): 132-8.

Apoptosis Induction by Ocimum sanctum Extract in LNCaP Prostate Cancer Cells.

Alternative Treatment/Prevention: Ocimum sanctum Extract

Dhandayuthapani, S., H. Azad, and A. Rathinavelu. “Apoptosis Induction by Ocimum Sanctum Extract in Lncap Prostate Cancer Cells.” [In eng]. J Med Food 18, no. 7 (Jul 2015): 776-85.

Apoptotic and anti-angiogenic effects of Salvia triloba extract in prostate cancer cell lines.

Alternative Treatment/Prevention: Salvia triloba extract

Atmaca, H., and E. Bozkurt. “Apoptotic and Anti-Angiogenic Effects of Salvia Triloba Extract in Prostate Cancer Cell Lines.” [In eng]. Tumour Biol 37, no. 3 (Mar 2016): 3639-46.

Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells.

Alternative Treatment/Prevention: Artocarpus altilis (Parkinson) Fosberg Extracts

Jeon, Y. J., S. N. Jung, H. Chang, J. Yun, C. W. Lee, J. Lee, S. Choi, et al. “Artocarpus Altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit Stat3 Activity in Prostate Cancer Du145 Cells.” [In eng]. Phytother Res 29, no. 5 (May 2015): 749-56.

Attenuation of nucleoside and anti-cancer nucleoside analog drug uptake in prostate cancer cells by Cimicifuga racemosa extract BNO-1055.

Alternative Treatment/Prevention: Cimicifuga racemosa extract

Dueregger, A., F. Guggenberger, J. Barthelmes, G. Stecher, M. Schuh, D. Intelmann, G. Abel, et al. “Attenuation of Nucleoside and Anti-Cancer Nucleoside Analog Drug Uptake in Prostate Cancer Cells by Cimicifuga Racemosa Extract Bno-1055.” [In eng]. Phytomedicine 20, no. 14 (Nov 15 2013): 1306-14.

Baseline prostate-specific antigen measurements and subsequent prostate cancer risk in the Danish Diet, Cancer and Health cohort.

Alternative Treatment/Prevention: Diet

Larsen, S. B., K. Brasso, P. Iversen, J. Christensen, M. Christiansen, S. Carlsson, H. Lilja, et al. “Baseline Prostate-Specific Antigen Measurements and Subsequent Prostate Cancer Risk in the Danish Diet, Cancer and Health Cohort.” [In eng]. Eur J Cancer 49, no. 14 (Sep 2013): 3041-8.

Baseline Selenium Status and Effects of Selenium and Vitamin E Supplementation on Prostate Cancer Risk.

Alternative Treatment/Prevention: Selenium, Vitamin E

Kristal, A. R., A. K. Darke, J. S. Morris, C. M. Tangen, P. J. Goodman, I. M. Thompson, F. L. Meyskens, Jr., et al. “Baseline Selenium Status and Effects of Selenium and Vitamin E Supplementation on Prostate Cancer Risk.” [In eng]. J Natl Cancer Inst 106, no. 3 (Mar 2014): djt456.

Chemoprevention of Prostate Cancer by Major Dietary Phytochemicals.

Alternative Treatment/Prevention: Diet (Phytochemicals)

Bommareddy, A., W. Eggleston, S. Prelewicz, A. Antal, Z. Witczak, D. F. McCune, and A. L. Vanwert. “Chemoprevention of Prostate Cancer by Major Dietary Phytochemicals.” [In eng]. Anticancer Res 33, no. 10 (Oct 2013): 4163-74.

Combination effects of dietary soy and methylselenocysteine in a mouse model of prostate cancer.

Alternative Treatment/Prevention: Diet

Christensen, M. J., T. E. Quiner, H. L. Nakken, E. D. Lephart, D. L. Eggett, and P. M. Urie. “Combination Effects of Dietary Soy and Methylselenocysteine in a Mouse Model of Prostate Cancer.” [In eng]. Prostate 73, no. 9 (Jun 2013): 986-95.

Crocus sativus stigma extract and its major constituent crocin possess significant antiproliferative properties against human prostate cancer.

Alternative Treatment/Prevention: Crocus sativus stigma extract

D’Alessandro, A. M., A. Mancini, A. R. Lizzi, A. De Simone, C. E. Marroccella, G. L. Gravina, C. Tatone, and C. Festuccia. “Crocus Sativus Stigma Extract and Its Major Constituent Crocin Possess Significant Antiproliferative Properties against Human Prostate Cancer.” [In eng]. Nutr Cancer 65, no. 6 (2013): 930-42.

Crude extract of Euphorbia formosana inhibits the migration and invasion of DU145 human prostate cancer cells: The role of matrix metalloproteinase-2/9 inhibition via the MAPK signaling pathway.

Alternative Treatment/Prevention: Euphorbia formosana extract

Yang, J. L., J. H. Lin, S. W. Weng, J. C. Chen, J. S. Yang, S. Amagaya, S. Funayana, et al. “Crude Extract of Euphorbia Formosana Inhibits the Migration and Invasion of Du145 Human Prostate Cancer Cells: The Role of Matrix Metalloproteinase-2/9 Inhibition Via the Mapk Signaling Pathway.” [In eng]. Mol Med Rep 7, no. 5 (May 2013): 1403-8.

Development of a standardized and effect-optimized herbal extract of Wedelia chinensis for prostate cancer

Alternative Treatment/Prevention: Wedelia chinensis extract

Tsai, C. H., S. F. Tzeng, S. C. Hsieh, C. Y. Lin, C. J. Tsai, Y. R. Chen, Y. C. Yang, et al. “Development of a Standardized and Effect-Optimized Herbal Extract of Wedelia Chinensis for Prostate Cancer.” [In eng]. Phytomedicine 22, no. 3 (Mar 15 2015): 406-14.

Dietary and serum lycopene levels in prostate cancer patients undergoing intensity-modulated radiation therapy.

Alternative Treatment/Prevention: Diet (lycopene levels)

Datta, M., M. L. Taylor, and B. Frizzell. “Dietary and Serum Lycopene Levels in Prostate Cancer Patients Undergoing Intensity-Modulated Radiation Therapy.” [In eng]. J Med Food 16, no. 12 (Dec 2013): 1131-7.

Dietary antioxidants and prostate cancer: a review.

Alternative Treatment/Prevention: Diet (antioxidants)

Vance, T. M., J. Su, E. T. Fontham, S. I. Koo, and O. K. Chun. “Dietary Antioxidants and Prostate Cancer: A Review.” [In eng]. Nutr Cancer 65, no. 6 (2013): 793-801.

Dietary botanicals for chemoprevention of prostate cancer.

Alternative Treatment/Prevention: Diet

Bhandari, P. “Dietary Botanicals for Chemoprevention of Prostate Cancer.” [In eng]. J Tradit Complement Med 4, no. 2 (Apr 2014): 75-6.

Dietary cadmium intake and risk of prostate cancer: a Danish prospective cohort study.

Alternative Treatment/Prevention: Diet (cadmium intake)

Eriksen, K. T., J. Halkjaer, J. R. Meliker, J. A. McElroy, M. Sorensen, A. Tjonneland, and O. Raaschou-Nielsen. “Dietary Cadmium Intake and Risk of Prostate Cancer: A Danish Prospective Cohort Study.” [In eng]. BMC Cancer 15 (Mar 26 2015): 177.

Dietary Carbohydrate and Prostate Cancer Risk: A Meta-Analysis.

Alternative Treatment/Prevention: Diet (Carbohydrates)

Zhai, L., S. Cheng, and D. Zhang. “Dietary Carbohydrate and Prostate Cancer Risk: A Meta-Analysis.” [In eng]. Nutr Cancer 67, no. 4 (2015): 594-602.

Dietary carrot consumption and the risk of prostate cancer.

Alternative Treatment/Prevention: Diet (Carrot consumption)

Xu, X., Y. Cheng, S. Li, Y. Zhu, X. Zheng, Q. Mao, and L. Xie. “Dietary Carrot Consumption and the Risk of Prostate Cancer.” [In eng]. Eur J Nutr 53, no. 8 (Dec 2014): 1615-23.

Dietary factors and risk for advanced prostate cancer.

Alternative Treatment/Prevention: Diet

Gathirua-Mwangi, W. G., and J. Zhang. “Dietary Factors and Risk for Advanced Prostate Cancer.” [In eng]. Eur J Cancer Prev 23, no. 2 (Mar 2014): 96-109.

Dietary Fat, Fatty Acids, and Risk of Prostate Cancer in the NIH-AARP Diet and Health Study.

Alternative Treatment/Prevention: Diet (Fat and Fatty acids)

Pelser, C., A. M. Mondul, A. R. Hollenbeck, and Y. Park. “Dietary Fat, Fatty Acids, and Risk of Prostate Cancer in the Nih-Aarp Diet and Health Study.” [In eng]. Cancer Epidemiol Biomarkers Prev 22, no. 4 (Apr 2013): 697-707.

Dietary fiber, whole grains, carbohydrate, glycemic index, and glycemic load in relation to risk of prostate cancer.

Alternative Treatment/Prevention: Diet (Carbohydrates)

Wang, R. J., J. E. Tang, Y. Chen, and J. G. Gao. “Dietary Fiber, Whole Grains, Carbohydrate, Glycemic Index, and Glycemic Load in Relation to Risk of Prostate Cancer.” [In eng]. Onco Targets Ther 8 (2015): 2415-26.

Dietary flavonoid and proanthocyanidin intakes and prostate cancer risk in a prospective cohort of US men.

Alternative Treatment/Prevention: Diet ( flavonoid and proanthocyanidin)

Wang, Y., V. L. Stevens, R. Shah, J. J. Peterson, J. T. Dwyer, S. M. Gapstur, and M. L. McCullough. “Dietary Flavonoid and Proanthocyanidin Intakes and Prostate Cancer Risk in a Prospective Cohort of Us Men.” [In eng]. Am J Epidemiol 179, no. 8 (Apr 15 2014): 974-86.

Dietary Lutein Modulates Growth and Survival Genes in Prostate Cancer Cells.

Alternative Treatment/Prevention: Diet (lutein)

Rafi, M. M., S. Kanakasabai, S. V. Gokarn, E. G. Krueger, and J. J. Bright. “Dietary Lutein Modulates Growth and Survival Genes in Prostate Cancer Cells.” [In eng]. J Med Food 18, no. 2 (Feb 2015): 173-81.

Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression.

Alternative Treatment/Prevention: Diet (lycopene)

Graff, R. E., A. Pettersson, R. T. Lis, T. U. Ahearn, S. C. Markt, K. M. Wilson, J. R. Rider, et al. “Dietary Lycopene Intake and Risk of Prostate Cancer Defined by Erg Protein Expression.” [In eng]. Am J Clin Nutr 103, no. 3 (Mar 2016): 851-60.

Dietary lycopene, angiogenesis, and prostate cancer: A prospective study in the prostate-specific antigen era.

Alternative Treatment/Prevention: Diet (lycopene)

Zu, K., L. Mucci, B. A. Rosner, S. K. Clinton, M. Loda, M. J. Stampfer, and E. Giovannucci. “Dietary Lycopene, Angiogenesis, and Prostate Cancer: A Prospective Study in the Prostate-Specific Antigen Era.” [In eng]. J Natl Cancer Inst 106, no. 2 (Feb 2014): djt430.

Dietary patterns after prostate cancer diagnosis in relation to disease-specific and total mortality.

Alternative Treatment/Prevention: Diet

Yang, M., S. A. Kenfield, E. L. Van Blarigan, J. L. Batista, H. D. Sesso, J. Ma, M. J. Stampfer, and J. E. Chavarro. “Dietary Patterns after Prostate Cancer Diagnosis in Relation to Disease-Specific and Total Mortality.” [In eng]. Cancer Prev Res (Phila) 8, no. 6 (Jun 2015): 545-51.

Dietary patterns and prostate cancer risk: Report from the population based ULSAM cohort study of Swedish men.

Alternative Treatment/Prevention: Diet

Ax, E., H. Garmo, B. Grundmark, A. Bill-Axelson, L. Holmberg, W. Becker, B. Zethelius, T. Cederholm, and P. Sjogren. “Dietary Patterns and Prostate Cancer Risk: Report from the Population Based Ulsam Cohort Study of Swedish Men.” [In eng]. Nutr Cancer 66, no. 1 (2014): 77-87.