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Statins – Adverse Effects – Update 2016

Posted May 1, 2017

High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial.

Statin: atorvastatin

Adverse Effect: kidney

Billings, F. T. th, P. A. Hendricks, J. S. Schildcrout, Y. Shi, M. R. Petracek, J. G. Byrne, and N. J. Brown. “High-Dose Perioperative Atorvastatin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial.” [In eng]. JAMA 315, no. 9 (Mar 01 2016): 877-88.

Protocol for analyses of adverse event data from randomized controlled trials of statin therapy.

Statin: statin

Adverse Effect: general adverse event statement

Protocol for Analyses of Adverse Event Data from Randomized Controlled Trials of Statin Therapy. [In eng]. Am Heart J 176 (Jun 2016): 63-9.

Statin-related myotoxicity

Statin: statin

Adverse Effect: muscle

Fernandes, V., M. J. Santos, and A. Perez. “Statin-Related Myotoxicity.” [In eng spa]. Endocrinol Nutr 63, no. 5 (May 2016): 239-49.

Statin Safety in Chinese: A Population-Based Study of Older Adults.

Statin: statin

Adverse Effect: muscle, kidney, mortality

Li, D. Q., R. B. Kim, E. McArthur, J. L. Fleet, R. A. Hegele, B. R. Shah, M. A. Weir, et al. “Statin Safety in Chinese: A Population-Based Study of Older Adults.” [In eng]. PLoS One 11, no. 3 (2016): e0150990.

Influence of simvastatin treatment on Toll-like receptor 4 in monocytes of peripheral blood in patients with sepsis and severe sepsis.

Statin: simvastatin

Adverse Effect: general statement re: adverse events

Shao, H., C. Wang, W. Zhu, X. Huang, Z. Guo, H. Zhang, and B. Qin. “[Influence of Simvastatin Treatment on Toll-Like Receptor 4 in Monocytes of Peripheral Blood in Patients with Sepsis and Severe Sepsis].” [In chi]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 28, no. 2 (Feb 2016): 159-63.

Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study.

Statin: statin

Adverse Effect: general statement re: adverse events

Wang, Y. C., T. C. Hsieh, C. L. Chou, J. L. Wu, and T. C. Fang. “Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study.” [In eng]. Medicine (Baltimore) 95, no. 2 (Jan 2016): e2487.

Meta-analysis of the effects of statins on perioperative outcomes in vascular and endovascular surgery.

Statin: statin

Adverse Effect: kidney

Antoniou, G. A., S. Hajibandeh, S. R. Vallabhaneni, J. A. Brennan, and F. Torella. “Meta-Analysis of the Effects of Statins on Perioperative Outcomes in Vascular and Endovascular Surgery.” [In eng]. J Vasc Surg 61, no. 2 (Feb 2015): 519-32 e1.

The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity.

Statin: simvastatin, atorvastatin or rosuvastatin

Adverse Effect: muscle

Bonifacio, A., G. M. Sanvee, J. Bouitbir, and S. Krahenbuhl. “The Akt/Mtor Signaling Pathway Plays a Key Role in Statin-Induced Myotoxicity.” [In eng]. Biochim Biophys Acta 1853, no. 8 (Aug 2015): 1841-9.

Myopathy induced by statin-ezetimibe combination: Evaluation of potential risk factors.

Statin: statin-ezetimibe

Adverse Effect: muscle

Brahmachari, B., and S. Chatterjee. “Myopathy Induced by Statin-Ezetimibe Combination: Evaluation of Potential Risk Factors.” [In eng]. Indian J Pharmacol 47, no. 5 (Sep-Oct 2015): 563-4.

Sleep changes following statin therapy: a systematic review and meta-analysis of randomized placebo-controlled polysomnographic trials.

Statin: statin

Adverse Effect: sleep

Broncel, M., P. Gorzelak-Pabis, A. Sahebkar, K. Serejko, S. Ursoniu, J. Rysz, M. Corina Serban, M. Mozdzan, and M. Banach. “Sleep Changes Following Statin Therapy: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Polysomnographic Trials.” [In eng]. Arch Med Sci 11, no. 5 (Oct 12 2015): 915-26.

Statin adverse effects: patients’ experiences and laboratory monitoring of muscle and liver injuries.

Statin: statin

Adverse Effect: muscle, liver

Chaipichit, N., J. Krska, T. Pratipanawatr, and N. Jarernsiripornkul. “Statin Adverse Effects: Patients’ Experiences and Laboratory Monitoring of Muscle and Liver Injuries.” [In eng]. Int J Clin Pharm 37, no. 2 (Apr 2015): 355-64.

Severe hepatic injury associated with different statins in patients with chronic liver disease: a nationwide population-based cohort study.

Statin: atorvastatin, lovastatin, fluvastatin, pravastatin, simvastatin, and rosuvastatin

Adverse Effect: liver

Chang, C. H., Y. C. Chang, Y. C. Lee, Y. C. Liu, L. M. Chuang, and J. W. Lin. “Severe Hepatic Injury Associated with Different Statins in Patients with Chronic Liver Disease: A Nationwide Population-Based Cohort Study.” [In eng]. J Gastroenterol Hepatol 30, no. 1 (Jan 2015): 155-62.

Periprocedural effects of statins on the incidence of contrast-induced acute kidney injury: a systematic review and meta-analysis of randomized controlled trials.

Statin: statin

Adverse Effect: kidney

Cheungpasitporn, W., C. Thongprayoon, W. Kittanamongkolchai, P. J. Edmonds, O. A. O’Corragain, N. Srivali, P. Ungprasert, and S. B. Erickson. “Periprocedural Effects of Statins on the Incidence of Contrast-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” [In eng]. Ren Fail 37, no. 4 (May 2015): 664-71.

Lack of adverse effect of statin therapy on common muscle-related adverse events.

Statin: statin

Adverse Effect: muscle

Collins, R. “Lack of Adverse Effect of Statin Therapy on Common Muscle-Related Adverse Events.” [In eng]. Eur J Prev Cardiol 22, no. 8 (Aug 2015): 1066.

From a fish tank injury to hospital haemodialysis: the serious consequences of drug interactions.

Statin: simvastatin

Adverse Effect: muscle, kidney

Hill, F. J., S. J. McCloskey, and N. Sheerin. “From a Fish Tank Injury to Hospital Haemodialysis: The Serious Consequences of Drug Interactions.” [In eng]. BMJ Case Rep 2015 (Jun 23 2015).

Effects of add-on lipid-modifying therapy on top of background statin treatment on major cardiovascular events: A meta-analysis of randomized controlled trials.

Statin: statin

Adverse Effect: liver, general

Ip, C. K., D. M. Jin, J. J. Gao, Z. Meng, J. Meng, Z. Tan, J. F. Wang, and D. F. Geng. “Effects of Add-on Lipid-Modifying Therapy on Top of Background Statin Treatment on Major Cardiovascular Events: A Meta-Analysis of Randomized Controlled Trials.” [In eng]. Int J Cardiol 191 (Jul 15 2015): 138-48.

Myopathy in older people receiving statin therapy: a systematic review and meta-analysis.

Statin: statin

Adverse Effect: muscle

Iwere, R. B., and J. Hewitt. “Myopathy in Older People Receiving Statin Therapy: A Systematic Review and Meta-Analysis.” [In eng]. Br J Clin Pharmacol 80, no. 3 (Sep 2015): 363-71.

Efficacy and Safety of Loading-Dose Rosuvastatin Therapy in Elderly Patients with Acute Coronary Syndromes Undergoing Elective Percutaneous Coronary Intervention.

Statin: rosuvastatin

Adverse Effect: general adverse event statement

Jiao, Y., F. Hu, Z. Zhang, K. Gong, X. Sun, A. Li, and N. Liu. “Efficacy and Safety of Loading-Dose Rosuvastatin Therapy in Elderly Patients with Acute Coronary Syndromes Undergoing Elective Percutaneous Coronary Intervention.” [In eng]. Clin Drug Investig 35, no. 12 (Dec 2015): 777-84.

eComment. Statin usage and acute renal injury: a long-drawn debate with inconclusive results.

Statin: statin

Adverse Effect: kidney

Kadan, M., I. Selcuk, B. Durgun, and S. Doganci. “Ecomment. Statin Usage and Acute Renal Injury: A Long-Drawn Debate with Inconclusive Results.” [In eng]. Interact Cardiovasc Thorac Surg 21, no. 4 (Oct 2015): 498.

Takotsubo cardiomyopathy with involvement of delayed-onset rhabdomyolysis and acute kidney injury after rosuvastatin treatment.

Statin: rosuvastatin

Adverse Effect: liver, muscle

Kamada, T., M. Hayashi, H. Yokoi, W. Fujiwara, D. Yoshikawa, D. Mukaide, Y. Sugishita, et al. “Takotsubo Cardiomyopathy with Involvement of Delayed-Onset Rhabdomyolysis and Acute Kidney Injury after Rosuvastatin Treatment.” [In eng]. Intern Med 54, no. 1 (2015): 31-5.

Pravastatin-induced rhabdomyolysis and purpura fulminans in a patient with chronic renal failure.

Statin: pravastatin

Adverse Effect: muscle

Kato, K., K. Onodera, Y. Iwasaki, M. Matsuda, T. Kawakami, M. Higuchi, Y. Kato, M. Taniguchi, and H. Furukawa. “Pravastatin-Induced Rhabdomyolysis and Purpura Fulminans in a Patient with Chronic Renal Failure.” [In eng]. Int J Surg Case Rep 8C (2015): 84-7.

Treatment Options for Statin-Associated Muscle Symptoms.

Statin: statin

Adverse Effect: muscle

Laufs, U., H. Scharnagl, M. Halle, E. Windler, M. Endres, and W. Marz. “Treatment Options for Statin-Associated Muscle Symptoms.” [In eng]. Dtsch Arztebl Int 112, no. 44 (Oct 30 2015): 748-55.

[STATINS FOR THE PREVENTION OF CARDIOVASCULAR DISEASE AND DIABETES INCIDENCE–THE BENEFITS VERSUS THE RISKS].

Statin: statin

Adverse Effect: diabetes

Lavie, G., and S. Cohen. “[Statins for the Prevention of Cardiovascular Disease and Diabetes Incidence–the Benefits Versus the Risks].” [In heb]. Harefuah 154, no. 6 (Jun 2015): 382-6, 404.

HMG CoA reductase inhibitors (statins) for preventing acute kidney injury after surgical procedures requiring cardiac bypass.

Statin: statin

Adverse Effect: general adverse event statement

Lewicki, M., I. Ng, and A. G. Schneider. “Hmg Coa Reductase Inhibitors (Statins) for Preventing Acute Kidney Injury after Surgical Procedures Requiring Cardiac Bypass.” [In eng]. Cochrane Database Syst Rev, no. 3 (Mar 11 2015): CD010480.

Safety of coadministration of ezetimibe and statins in patients with hypercholesterolaemia: a meta-analysis.

Statin: statin

Adverse Effect: general, GI, liver

Luo, L., X. Yuan, W. Huang, F. Ren, H. Zhu, Y. Zheng, and L. Tang. “Safety of Coadministration of Ezetimibe and Statins in Patients with Hypercholesterolaemia: A Meta-Analysis.” [In eng]. Intern Med J 45, no. 5 (May 2015): 546-57.

Risk identification and possible countermeasures for muscle adverse effects during statin therapy.

Statin: statin

Adverse Effect: muscle

Magni, P., C. Macchi, B. Morlotti, C. R. Sirtori, and M. Ruscica. “Risk Identification and Possible Countermeasures for Muscle Adverse Effects During Statin Therapy.” [In eng]. Eur J Intern Med 26, no. 2 (Mar 2015): 82-8.