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Stroke Therapeutics – Alternative Medicine

Posted January 4, 2012

Effect of combined therapy with hyperbaric oxygen and antioxidant on infarct volume after permanent focal cerebral ischemia.

Acka, G., A. Sen, Z. Canakci, S. Yildiz, A. Akin, G. Uzun, H. Cermik, I. Yildirim, and S. Kokpinar. 2007. Effect of combined therapy with hyperbaric oxygen and antioxidant on infarct volume after permanent focal cerebral ischemia. Physiol Res 56 (3):369-73.

Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging.

Slemmer, J. E., J. J. Shacka, M. I. Sweeney, and J. T. Weber. 2008. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem 15 (4):404-14.

Insulin in the treatment of ischemic stroke

Samson, Y., M. Bruandet, M. Lejeune, S. Deltour, and A. Grimaldi. 2006. [Insulin in the treatment of ischemic stroke]. Presse Med 35 (4 Pt 2):696-8.

Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients

Ho, G. Y., J. W. Eikelboom, G. J. Hankey, C. R. Wong, S. L. Tan, J. B. Chan, and C. P. Chen. 2006. Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients. Stroke 37 (2):456-60.

Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: Dose-response and therapeutic window

Ley, J. J., L. Belayev, I. Saul, D. A. Becker, and M. D. Ginsberg. 2007. Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: dose-response and therapeutic window. Brain Res 1180:101-10.

A randomised controlled trial evaluating family mediated exercise (FAME) therapy following stroke

Galvin, R., T. Cusack, and E. Stokes. 2008. A randomised controlled trial evaluating family mediated exercise (FAME) therapy following stroke. BMC Neurol 8:22.

Combined L-arginine and antioxidative vitamin treatment mollifies ischemia-reperfusion injury of skeletal muscle

Nanobashvili, J., C. Neumayer, A. Fuegl, A. Punz, R. Blumer, M. Mittlbock, M. Prager, P. Polterauer, L. W. Dobrucki, I. Huk, and T. Malinski. 2004. Combined L-arginine and antioxidative vitamin treatment mollifies ischemia-reperfusion injury of skeletal muscle. J Vasc Surg 39 (4):868-77.

Task-oriented aerobic exercise in chronic hemiparetic stroke: Training protocols and treatment effects

Macko, R. F., F. M. Ivey, and L. W. Forrester. 2005. Task-oriented aerobic exercise in chronic hemiparetic stroke: training protocols and treatment effects. Top Stroke Rehabil 12 (1):45-57.

Daily functioning and quality of life in a randomized controlled trial of therapeutic exercise for subacute stroke survivors

Studenski, S., P. W. Duncan, S. Perera, D. Reker, S. M. Lai, and L. Richards. 2005. Daily functioning and quality of life in a randomized controlled trial of therapeutic exercise for subacute stroke survivors. Stroke 36 (8):1764-70.

Does therapeutic facilitation add to locomotor outcome of body weight-supported treadmill training in nonambulatory patients with stroke? A randomized controlled trial

Yagura, H., M. Hatakenaka, and I. Miyai. 2006. Does therapeutic facilitation add to locomotor outcome of body weight–supported treadmill training in nonambulatory patients with stroke? A randomized controlled trial. Arch Phys Med Rehabil 87 (4):529-35.

Effects of augmented exercise therapy time after stroke: A meta-analysis

Kwakkel, G., R. van Peppen, R. C. Wagenaar, S. Wood Dauphinee, C. Richards, A. Ashburn, K. Miller, N. Lincoln, C. Partridge, I. Wellwood, and P. Langhorne. 2004. Effects of augmented exercise therapy time after stroke: a meta-analysis. Stroke 35 (11):2529-39.

Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: Single versus multiple doses and gender difference

Du, Y., and K. M. Ko. 2005. Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: single versus multiple doses and gender difference. Life Sci 77 (22):2770-82.

Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart

Wang, P., S. G. Lloyd, and J. C. Chatham. 2005. Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart. Circulation 111 (16):2066-72.

Hyperhomocysteinemia, ischemic stroke, and B-vitamin treatment: the jury is still out.

Murthy, J. M. 2005. Hyperhomocysteinemia, ischemic stroke, and B-vitamin treatment: the jury is still out. Neurol India 53 (3):271-2.

Insulin in the treatment of ischemic stroke

Samson, Y., M. Bruandet, M. Lejeune, S. Deltour, and A. Grimaldi. 2006. [Insulin in the treatment of ischemic stroke]. Presse Med 35 (4 Pt 2):696-8.

Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy.

Garg, R., A. Chaudhuri, F. Munschauer, and P. Dandona. 2006. Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy. Stroke 37 (1):267-73.

Antioxidant strategies in the treatment of stroke.

Margaill, I., M. Plotkine, and D. Lerouet. 2005. Antioxidant strategies in the treatment of stroke. Free Radic Biol Med 39 (4):429-43.

Effect of one week treatment with Ginkgo biloba extract (EGb761) on ischemia-induced infarct volume in gerbils

Chung, S. Y., M. F. Wang, J. Y. Lin, M. C. Lin, H. M. Liu, and F. C. Cheng. 2003. Effect of one week treatment with Ginkgo biloba extract (EGb761) on ischemia-induced infarct volume in gerbils. Am J Chin Med 31 (4):533-42.

The impact of increased duration of exercise therapy on functional recovery following stroke – what is the evidence?

Galvin, R., B. Murphy, T. Cusack, and E. Stokes. 2008. The impact of increased duration of exercise therapy on functional recovery following stroke–what is the evidence? Top Stroke Rehabil 15 (4):365-77.

Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study.

Kelly, P. J., J. D. Morrow, M. Ning, W. Koroshetz, E. H. Lo, E. Terry, G. L. Milne, J. Hubbard, H. Lee, E. Stevenson, M. Lederer, and K. L. Furie. 2008. Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study. Stroke 39 (1):100-4.

B-group vitamin supplementation mitigates oxidative damage after acute ischaemic stroke

Ullegaddi, R., H. J. Powers, and S. E. Gariballa. 2004. B-group vitamin supplementation mitigates oxidative damage after acute ischaemic stroke. Clin Sci (Lond) 107 (5):477-84.

The free-radical processes and antioxidant therapy in brain ischemia

Solov’eva, EIu, O. P. Mironova, O. A. Baranova, E. M. Bekman, A. V. Aseichev, A. I. Fedin, and O. A. Azizova. 2008. [The free-radical processes and antioxidant therapy in brain ischemia]. Zh Nevrol Psikhiatr Im S S Korsakova 108 (6):37-42.

Constraint-induced movement therapy and rehabilitation exercises lessen motor deficits and volume of brain injury after striatal hemorrhagic stroke in rats

DeBow, S. B., M. L. Davies, H. L. Clarke, and F. Colbourne. 2003. Constraint-induced movement therapy and rehabilitation exercises lessen motor deficits and volume of brain injury after striatal hemorrhagic stroke in rats. Stroke 34 (4):1021-6.

Randomized clinical trial of therapeutic exercise in subacute stroke

Duncan, P., S. Studenski, L. Richards, S. Gollub, S. M. Lai, D. Reker, S. Perera, J. Yates, V. Koch, S. Rigler, and D. Johnson. 2003. Randomized clinical trial of therapeutic exercise in subacute stroke. Stroke 34 (9):2173-80.

Therapeutic exercise and depressive symptoms after stroke

Lai, S. M., S. Studenski, L. Richards, S. Perera, D. Reker, S. Rigler, and P. W. Duncan. 2006. Therapeutic exercise and depressive symptoms after stroke. J Am Geriatr Soc 54 (2):240-7.

Risk of stroke and hormone replacement therapy: A prospective cohort study

Li, C., G. Engstrom, B. Hedblad, G. Berglund, and L. Janzon. 2006. Risk of stroke and hormone replacement therapy. A prospective cohort study. Maturitas 54 (1):11-8.

Nonfatal stroke, cardiac disease, and diabetes mellitus in hypopituitary patients on hormone replacement including growth hormone.

Holmer, H., J. Svensson, L. Rylander, G. Johannsson, T. Rosen, B. A. Bengtsson, M. Thoren, C. Hoybye, M. Degerblad, M. Bramnert, E. Hagg, B. Eden Engstrom, B. Ekman, B. Norrving, L. Hagmar, and E. M. Erfurth. 2007. Nonfatal stroke, cardiac disease, and diabetes mellitus in hypopituitary patients on hormone replacement including growth hormone. J Clin Endocrinol Metab 92 (9):3560-7.

Hormone replacement therapy and stroke – Clinical trials review

Brass, L. M. 2004. Hormone replacement therapy and stroke: clinical trials review. Stroke 35 (11 Suppl 1):2644-7.

Hormone replacement therapy and cardiovascular disease: increased risks of venous thromboembolism and stroke, and no protection from coronary heart disease.

Lowe, G. D. 2004. Hormone replacement therapy and cardiovascular disease: increased risks of venous thromboembolism and stroke, and no protection from coronary heart disease. J Intern Med 256 (5):361-74.

Effect of Intensive Lipid Lowering, With or Without Antioxidant Vitamins, Compared With Moderate Lipid Lowering on Myocardial Ischemia in Patients With Stable Coronary Artery Disease. The Vascular Basis for the Treatment of Myocardial Ischemia Study

Stone, P. H., D. M. Lloyd-Jones, S. Kinlay, B. Frei, W. Carlson, J. Rubenstein, T. C. Andrews, M. Johnstone, G. Sopko, H. Cole, J. Orav, A. P. Selwyn, and M. A. Creager. 2005. Effect of intensive lipid lowering, with or without antioxidant vitamins, compared with moderate lipid lowering on myocardial ischemia in patients with stable coronary artery disease: the Vascular Basis for the Treatment of Myocardial Ischemia Study. Circulation 111 (14):1747-55.

Intensive insulin therapy during cardiac surgery did not reduce mortality or morbidity but increased risk for stroke.

Jain, M. 2007. Intensive insulin therapy during cardiac surgery did not reduce mortality or morbidity but increased risk for stroke. ACP J Club 147 (1):2.

Vitamin supplementation and risk of stroke.

Wald, D. S. 2004. Vitamin supplementation and risk of stroke. JAMA 291 (18):2191; author reply 2191-2.

Antioxidant supplementation enhances antioxidant capacity and mitigates oxidative damage following acute ischaemic stroke.

Ullegaddi, R., H. J. Powers, and S. E. Gariballa. 2005. Antioxidant supplementation enhances antioxidant capacity and mitigates oxidative damage following acute ischaemic stroke. Eur J Clin Nutr 59 (12):1367-73.

Losing Weight as a Countermeasure to Diabetes, Hypertension, Stroke … The Therapeutic Potential is Enormous

Wirth, A. 2003. [Losing weight as a countermeasure to diabetes, hypertension, stroke… The therapeutic potential is enormous]. MMW Fortschr Med 145 (42):29.

Vitamin Supplementation and Risk of Stroke 1 (multiple letters)

Aguirre, C., G. Ruiz-Irastorza, M. V. Egurbide, and A. Martinez-Berriotxoa. 2004. Vitamin supplementation and risk of stroke. JAMA 291 (18):2191; author reply 2191-2.

Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: A randomized controlled trial

Ullegaddi, R., H. J. Powers, and S. E. Gariballa. 2006. Antioxidant supplementation with or without B-group vitamins after acute ischemic stroke: a randomized controlled trial. JPEN J Parenter Enteral Nutr 30 (2):108-14.