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Vitamin D – Treatment of Viruses and Flu

Posted January 2, 2012

On the epidemiology of influenza.

Cannell, J. J., M. Zasloff, C. F. Garland, R. Scragg, and E. Giovannucci. 2008. On the epidemiology of influenza. Virol J 5:29.

Vitamin D: a D-Lightful health perspective.

Holick, M. F. 2008. Vitamin D: a D-Lightful health perspective. Nutr Rev 66 (10 Suppl 2):S182-94.

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3..

Gombart, A. F., N. Borregaard, and H. P. Koeffler. 2005. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J 19 (9):1067-77.

Antimicrobial peptides in the airway.

Laube, D. M., S. Yim, L. K. Ryan, K. O. Kisich, and G. Diamond. 2006. Antimicrobial peptides in the airway. Curr Top Microbiol Immunol 306:153-82.

The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor.

Tjabringa, G. S., J. Aarbiou, D. K. Ninaber, J. W. Drijfhout, O. E. Sorensen, N. Borregaard, K. F. Rabe, and P. S. Hiemstra. 2003. The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. J Immunol 171 (12):6690-6.

Inducing endogenous antimicrobial peptides to battle infections.

Zasloff, M. 2006. Inducing endogenous antimicrobial peptides to battle infections. Proc Natl Acad Sci U S A 103 (24):8913-4.

Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense.

Hansdottir, S., M. M. Monick, S. L. Hinde, N. Lovan, D. C. Look, and G. W. Hunninghake. 2008. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol 181 (10):7090-9.

Plasma 25-hydroxyvitamin D levels in young children undergoing placement of tympanostomy tubes.

Linday, L. A., R. D. Shindledecker, J. N. Dolitsky, T. C. Chen, and M. F. Holick. 2008. Plasma 25-hydroxyvitamin D levels in young children undergoing placement of tympanostomy tubes. Ann Otol Rhinol Laryngol 117 (10):740-4.

Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression.

Wang, T. T., F. P. Nestel, V. Bourdeau, Y. Nagai, Q. Wang, J. Liao, L. Tavera-Mendoza, R. Lin, J. W. Hanrahan, S. Mader, and J. H. White. 2004. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 173 (5):2909-12.

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.

Liu, P. T., S. Stenger, H. Li, L. Wenzel, B. H. Tan, S. R. Krutzik, M. T. Ochoa, J. Schauber, K. Wu, C. Meinken, D. L. Kamen, M. Wagner, R. Bals, A. Steinmeyer, U. Zugel, R. L. Gallo, D. Eisenberg, M. Hewison, B. W. Hollis, J. S. Adams, B. R. Bloom, and R. L. Modlin. 2006. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311 (5768):1770-3.