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Vitamin K2 – Benefits

Posted January 4, 2012

Dietary vitamin K2 supplement improves bone status after lung and heart transplantation

Subject: Osteoporosis

Forli, L., J. Bollerslev, S. Simonsen, G. A. Isaksen, K. E. Kvamsdal, K. Godang, G. Gadeholt, A. H. Pripp, and O. Bjortuft. Dietary vitamin K2 supplement improves bone status after lung and heart transplantation. Transplantation 89 (4):458-64.

Concurrent treatment of osteoporosis with bisphosphonate and vitamin K2

Subject: Osteoporosis

Shiraki, M. 2004. [Concurrent treatment of osteoporosis with bisphosphonate and vitamin K2]. Nihon Rinsho 62 Suppl 2:466-9.

Combined treatment with vitamin K2 and bisphosphonate in postmenopausal women with osteoporosis.

Subject: Osteoporosis

Iwamoto, J., T. Takeda, and S. Ichimura. 2003. Combined treatment with vitamin k2 and bisphosphonate in postmenopausal women with osteoporosis. Yonsei Med J 44 (5):751-6

Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines.

Subject: Lung Cancer

Yokoyama, T., K. Miyazawa, T. Yoshida, and K. Ohyashiki. 2005. Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines. Int J Oncol 26 (1):33-40.

Bone quality and vitamin K2 in type 2 diabetes: Review of preclinical and clinical studies

Subject: Bone Quality

Iwamoto, J., Y. Sato, T. Takeda, and H. Matsumoto. Bone quality and vitamin K2 in type 2 diabetes: review of preclinical and clinical studies. Nutr Rev 69 (3):162-7.

Apoptosis of liver cancer cells by vitamin K2 and enhancement by MEK inhibition.

Subject: Liver Cancer

Matsumoto, K., J. Okano, T. Nagahara, and Y. Murawaki. 2006. Apoptosis of liver cancer cells by vitamin K2 and enhancement by MEK inhibition. Int J Oncol 29 (6):1501-8.

Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer.

Subject: Lung Cancer

Yoshida, T., K. Miyazawa, I. Kasuga, T. Yokoyama, K. Minemura, K. Ustumi, M. Aoshima, and K. Ohyashiki. 2003. Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer. Int J Oncol 23 (3):627-32.

A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy.

Subject: Osteoporosis

Iwamoto, I., S. Kosha, S. Noguchi, M. Murakami, T. Fujino, T. Douchi, and Y. Nagata. 1999. A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy. Maturitas 31 (2):161-4.

Biological effects of vitamin K2 on bone quality

Subject: Bone Quality

Amizuka, N., M. Li, Y. Guo, Z. Liu, R. Suzuki, and T. Yamamoto. 2009. [Biological effects of vitamin K2 on bone quality]. Clin Calcium 19 (12):1788-96.

Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol.

Subject: Bone Quality

Inoue, T., T. Sugiyama, T. Matsubara, S. Kawai, and S. Furukawa. 2001. Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol. Endocr J 48 (1):11-8.

Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei.

Subject: Ovarian Cancer

Sibayama-Imazu, T., Y. Fujisawa, Y. Masuda, T. Aiuchi, S. Nakajo, H. Itabe, and K. Nakaya. 2008. Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei. J Cancer Res Clin Oncol 134 (7):803-12.

Improvement of vitamin K status of breastfeeding infants with maternal supplement of vitamin K2 (MK40)

Subject: Breast Feeding

Nishiguchi, T., M. Yamashita, M. Maeda, K. Matsuyama, T. Kobayashi, N. Kanayama, and T. Terao. 2002. Improvement of vitamin K status of breastfeeding infants with maternal supplement of vitamin K2 (MK40). Semin Thromb Hemost 28 (6):533-8.

Growth inhibitory effects of vitamin K2 on colon cancer cell lines via different types of cell death including autophagy and apoptosis

Subject: Colon Cancer

Kawakita, H., A. Tsuchida, K. Miyazawa, M. Naito, M. Shigoka, B. Kyo, M. Enomoto, T. Wada, K. Katsumata, K. Ohyashiki, M. Itoh, A. Tomoda, and T. Aoki. 2009. Growth inhibitory effects of vitamin K2 on colon cancer cell lines via different types of cell death including autophagy and apoptosis. Int J Mol Med 23 (6):709-16.

Efficacy of combined administration of vitamin D3 and vitamin K2 for primary osteoporosis

Subject: Osteoporosis

Iwamoto, J. 2002. [Efficacy of combined administration of vitamin D3 and vitamin K2 for primary osteoporosis]. Clin Calcium 12 (7):955-65.

Effects of vitamin K2 on osteoporosis

Subject: Osteoporosis

Iwamoto, J., T. Takeda, and Y. Sato. 2004. Effects of vitamin K2 on osteoporosis. Curr Pharm Des 10 (21):2557-76.

Effects of vitamin K2 administration in the patients with severely motor and intellectual disabilities: assessment of bone metabolic marker and bone mineral density

Subject: Bone Quality

Tanaka, Y., and R. Shibata. 2000. [Effects of vitamin K2 administration in the patients with severely motor and intellectual disabilities: assessment of bone metabolic marker and bone mineral density]. No To Hattatsu 32 (6):491-6.

Effect of vitamin K2 and estrogen administration on bone formation

Subject: Bone Quality

Aisaka, K. 2004. [Effect of vitamin K2 and estrogen administration on bone formation]. Nihon Rinsho 62 Suppl 2:484-7.

Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa

Subject: Osteoporosis

Iketani, T., N. Kiriike, Murray, B. Stein, K. Nagao, T. Nagata, N. Minamikawa, A. Shidao, and H. Fukuhara. 2003. Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa. Psychiatry Res 117 (3):259-69.

Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women.

Subject: Osteoporosis/coagulofibrinolysis function

Ushiroyama, T., A. Ikeda, and M. Ueki. 2002. Effect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas 41 (3):211-21.

Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis.

Subject: Osteoporosis

Iwamoto, J., T. Takeda, and S. Ichimura. 2000. Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis. J Orthop Sci 5 (6):546-51.

Vitamin K2 (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis

Subject: Osteoporosis

Miki, T., K. Nakatsuka, H. Naka, K. Kitatani, S. Saito, H. Masaki, Y. Tomiyoshi, H. Morii, and Y. Nishizawa. 2003. Vitamin K(2) (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis. J Bone Miner Metab 21 (3):161-5.

Vitamin K2: A novel therapy for osteoporosis

Subject: Osteoporosis

Prabhoo, R., and T. R. Prabhoo. Vitamin K2: a novel therapy for osteoporosis. J Indian Med Assoc 108 (4):253-4, 256-8.

Vitamin K2-mediated apoptosis in cancer cells: role of mitochondrial transmembrane potential.

Subject: Cancer

Shibayama-Imazu, T., T. Aiuchi, and K. Nakaya. 2008. Vitamin K2-mediated apoptosis in cancer cells: role of mitochondrial transmembrane potential. Vitam Horm 78:211-26.

Vitamin K2-derived compounds induce growth inhibition in radioresistant cancer cells

Subject: Cancer

Amalia, H., R. Sasaki, Y. Suzuki, Y. Demizu, T. Bito, H. Nishimura, Y. Okamoto, K. Yoshida, D. Miyawaki, T. Kawabe, Y. Mizushina, and K. Sugimura. Vitamin K2-derived compounds induce growth inhibition in radioresistant cancer cells. Kobe J Med Sci 56 (2):E38-49.

Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia.

Subject: Osteoporosis

Purwosunu, Y., Muharram, I. A. Rachman, S. Reksoprodjo, and A. Sekizawa. 2006. Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia. J Obstet Gynaecol Res 32 (2):230-4.

Vitamin K2 treatment for osteoporosis: what is the evidence today?

Subject: Osteoporosis

Ishida, Y. 2007. [Vitamin K2 treatment for osteoporosis: what is the evidence today?]. Nihon Rinsho 65 Suppl 9:409-14.

Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women.

Subject: Osteoporosis

Knapen, M. H., L. J. Schurgers, and C. Vermeer. 2007. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int 18 (7):963-72.

Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial.

Subject: Osteoporosis

Emaus, N., C. G. Gjesdal, B. Almas, M. Christensen, A. S. Grimsgaard, G. K. Berntsen, L. Salomonsen, and V. Fonnebo. Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial. Osteoporos Int 21 (10):1731-40.

Vitamin K2 supplementation does not influence bone loss in early menopausal women: A randomised double-blind placebo-controlled trial

Subject: Osteoporosis

Emaus, N., C. G. Gjesdal, B. Almas, M. Christensen, A. S. Grimsgaard, G. K. Berntsen, L. Salomonsen, and V. Fonnebo. Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial. Osteoporos Int 21 (10):1731-40.

Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR.

Subject: Osteoporosis

Tabb, M. M., A. Sun, C. Zhou, F. Grun, J. Errandi, K. Romero, H. Pham, S. Inoue, S. Mallick, M. Lin, B. M. Forman, and B. Blumberg. 2003. Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. J Biol Chem 278 (45):43919-27.

Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis.

Subject: Bone Resorption

Kameda, T., K. Miyazawa, Y. Mori, T. Yuasa, M. Shiokawa, Y. Nakamaru, H. Mano, Y. Hakeda, A. Kameda, and M. Kumegawa. 1996. Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochem Biophys Res Commun 220 (3):515-9.

Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG)

Subject: Osteoporosis

Sasaki, N., E. Kusano, H. Takahashi, Y. Ando, K. Yano, E. Tsuda, and Y. Asano. 2005. Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). J Bone Miner Metab 23 (1):41-7.

Vitamin K2 in the treatment of osteoporosis

Subject: Osteoporosis

Shiraki, M. 2002. [Vitamin K2 in the treatment of osteoporosis]. Nihon Rinsho 60 Suppl 3:340-9.

Vitamin K2 in bone metabolism and osteoporosis

Subject: Osteoporosis

Plaza, S. M., and D. W. Lamson. 2005. Vitamin K2 in bone metabolism and osteoporosis. Altern Med Rev 10 (1):24-35.

Vitamin K2 improves the hematopoietic supportive functions of bone marrow stromal cells in vitro: a possible mechanism of improvement of cytopenia for refractory anemia in response to vitamin K2 therapy.

Subject: Anemia

Miyazawa, K., and S. Aizawa. 2004. Vitamin K2 improves the hematopoietic supportive functions of bone marrow stromal cells in vitro: a possible mechanism of improvement of cytopenia for refractory anemia in response to vitamin K2 therapy. Stem Cells Dev 13 (5):449-51.

Vitamin K2 as a protector of bone health and beyond

Subject: Osteoporosis

Kaneki, M. 2005. [Vitamin K2 as a protector of bone health and beyond]. Clin Calcium 15 (4):605-10.

Vitamin K2 as a potential therapeutic agent for glucocorticoid-induced osteoporosis

Subject: Osteoporosis

Tanana, I., and H. Oshima. 2006. [Vitamin K2 as a potential therapeutic agent for glucocorticoid-induced osteoporosis]. Clin Calcium 16 (11):1851-7.

Vitamin K2 alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level

Subject: Bone Disease

Ochiai, M., A. Nakashima, N. Takasugi, K. Kiribayashi, T. Kawai, K. Usui, K. Shigemoto, N. Hamaguchi, N. Kohno, and N. Yorioka. Vitamin K alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level. Nephron Clin Pract 117 (1):c15-9.

Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver.

Subject: Osteoporosis

Shiomi, S., S. Nishiguchi, S. Kubo, A. Tamori, D. Habu, T. Takeda, and H. Ochi. 2002. Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver. Am J Gastroenterol 97 (4):978-8.

Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.

Subject: Osteoporosis

Shiraki, M., Y. Shiraki, C. Aoki, and M. Miura. 2000. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res 15 (3):515-21.

Vitamin K2 (menatetrenone) and bone quality

Subject: Osteoporosis

Iinuma, N. 2005. [Vitamin K2 (menatetrenone) and bone quality]. Clin Calcium 15 (6):1034-9.

Vitamin K-containing dietary supplements: Comparison of synthetic vitamin K1 and natto-derived menaquinone-7

Subject: Blood Clotting

Schurgers, L. J., K. J. Teunissen, K. Hamulyak, M. H. Knapen, H. Vik, and C. Vermeer. 2007. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood 109 (8):3279-83.

Vitamin K(2) (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis.

Subject: Osteoporosis

Miki, T., K. Nakatsuka, H. Naka, K. Kitatani, S. Saito, H. Masaki, Y. Tomiyoshi, H. Morii, and Y. Nishizawa. 2003. Vitamin K(2) (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis. J Bone Miner Metab 21 (3):161-5.

Vitamin D3, vitamin K2, and warfarin regulate bone metabolism in human paranasal sinus bones.

Subject: Bone Metabolism

Sugimoto, I., K. Hirakawa, T. Ishino, S. Takeno, and K. Yajin. 2007. Vitamin D3, vitamin K2, and warfarin regulate bone metabolism in human paranasal sinus bones. Rhinology 45 (3):208-13.

Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide.

Subject: Bone Resorption

Somekawa, Y., M. Chigughi, M. Harada, and T. Ishibashi. 1999. Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide. J Clin Endocrinol Metab 84 (8):2700-4.

Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis.

Subject: Osteoporosis

Iwamoto, J., T. Takeda, and S. Ichimura. 2003. Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. Keio J Med 52 (3):147-50.

Treatment of primary osteoporosis with vitamin K2

Subject: Osteoporosis

Hosoi, T. 2007. [Treatment of primary osteoporosis with vitamin K2]. Clin Calcium 17 (11):1727-30.

Treatment of osteoporosis with vitamin K2

Subject: Osteoporosis

Shiraki, M. 2004. [Treatment of osteoporosis with vitamin K2]. Nihon Rinsho 62 Suppl 2:404-9.

Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women.

Subject: Bone Resorption

Ozuru, R., T. Sugimoto, T. Yamaguchi, and K. Chihara. 2002. Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women. Endocr J 49 (3):363-70.

Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women

Subject: Bone Resorption

Ozuru, R., T. Sugimoto, T. Yamaguchi, and K. Chihara. 2002. Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women. Endocr J 49 (3):363-70.

The interplay of magnesium and vitamin K2 on bone mineralization

Subject: Bone Quality

Amizuka, N., M. Li, and T. Maeda. 2005. [The interplay of magnesium and vitamin K2 on bone mineralization]. Clin Calcium 15 (7):57-61.

The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain.

Subject: Bone Resorption

Hara, K., Y. Akiyama, T. Nakamura, S. Murota, and I. Morita. 1995. The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. Bone 16 (2):179-84.

Role of vitamin K2 in the treatment of postmenopausal osteoporosis.

Subject: Osteoporosis

Iwamoto, J., T. Takeda, and Y. Sato. 2006. Role of vitamin K2 in the treatment of postmenopausal osteoporosis. Curr Drug Saf 1 (1):87-97.

Randomized pilot trial of vitamin K2 for bone loss in patients with primary biliary cirrhosis.

Subject: Osteoporosis

Nishiguchi, S., S. Shimoi, H. Kurooka, A. Tamori, D. Habu, T. Takeda, and S. Kubo. 2001. Randomized pilot trial of vitamin K2 for bone loss in patients with primary biliary cirrhosis. J Hepatol 35 (4):543-5.

Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine.

Subject: Bone Resorption

Yonemura, K., H. Fukasawa, Y. Fujigaki, and A. Hishida. 2004. Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. Am J Kidney Dis 43 (1):53-60.

Production of superoxide and dissipation of mitochondrial transmembrane potential by vitamin K2 trigger apoptosis in human ovarian cancer TYK-nu cells.

Subject: Ovarian Cancer

Shibayama-Imazu, T., I. Sonoda, S. Sakairi, T. Aiuchi, W. W. Ann, S. Nakajo, H. Itabe, and K. Nakaya. 2006. Production of superoxide and dissipation of mitochondrial transmembrane potential by vitamin K2 trigger apoptosis in human ovarian cancer TYK-nu cells. Apoptosis 11 (9):1535-43.